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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Regulating role of fetal thyroid hormones on placental mitochondrial DNA methylation: epidemiological evidence from the ENVIRONAGE birth cohort study

Fig. 2

Estimated proportion of effects of FT3 exposure on mtDNA content mediated by mtDNA methylation. The figure displays placental mtDNA methylation as mediator (left panel: MT-RNR1; right panel: D-loop), the estimates of indirect effect (IE), the estimates of the direct effect (DE), and proportion of mediation (IE/DE + IE). The effects represent a relative change (%) in placental mtDNA content for an increment between the 10th-90th percentile of FT3. All models were adjusted for maternal age, pre-pregnancy BMI, gestational age, newborn’s sex, smoking status, parity, maternal education, ethnicity, and cord plasma insulin level. * p-value < 0.05

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