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Table 5 A summary of the within-subjects correlation between methylation beta levels in blood and matched lip or palate tissue. Results are shown before and after adjustment for principal components (PCs) to account for cellular heterogeneity and technical factors

From: Distinct DNA methylation profiles in subtypes of orofacial cleft

  Before adjustment for PCs After adjustment for PCs
Median rho (IQR) Median P (IQR) % positive correlation % with P < 0.05 Median rho (IQR) Median P (IQR) % positive correlation % with P < 0.05
1063 CpGs in CPOvsCLO DMRs Blood vs lip 0.11 (0.01, 0.20) 0.28 (0.05, 0.62) 78% 25% 0.09 (−0.003, 0.20) 0.31 (0.05, 0.62) 74% 25%
Blood vs palate 0.12 (0.01, 0.23) 0.31 (0.08, 0.64) 77% 22% 0.10 (−0.01, 0.21) 0.34 (0.10, 0.65) 73% 19%
82 CpGs in CPOvsCLP DMRs Blood vs lip 0.21 (0.04, 0.36) 0.04 (0.001, 0.37) 78% 33% 0.17 (0.04, 0.30) 0.09 (0.005, 0.42) 74% 25%
Blood vs palate 0.27 (0.07, 0.49) 0.04 (0.0002, 0.39) 77% 22% 0.21 (0.03, 0.38) 0.31 (0.004, 0.59) 73% 19%
25 CpGs in CLOvsCLP DMRs Blood vs lip 0.19 (0.07, 0.33) 0.07 (0.001, 0.46) 84% 44% 0.13 (0.07, 0.33) 0.22 (0.002, 0.34) 84% 40%
Blood vs palate 0.17 (0.08, 0.39) 0.31 (0.003, 0.53) 84% 40% 0.25 (0.15, 0.33) 0.06 (0.01, 0.26) 96% 48%
483,437 CpGs outside of DMRs Blood vs lip 0.05 (−0.03, 0.14) 0.41 (0.14, 0.70) 67% 15% 0.04 (−0.04, 0.12) 0.43 (0.16, 0.71) 62% 13%
Blood vs palate 0.08 (−0.02, 0.18) 0.40 (0.14, 0.70) 69% 14% 0.05 (−0.05, 0.15) 0.44 (0.17, 0.72) 62% 11%