Table 3 Top five DMRs with the largest regression coefficients and Sidak-corrected P values <0.05
From: Distinct DNA methylation profiles in subtypes of orofacial cleft
EWAS | DMR | Genea | N CpGs | Sidak-corrected P value | Range of regression coefficients |
|---|---|---|---|---|---|
CLOvsCLP (blood) | Chr6:160241105-160241557 | PNLDC1 | 4 | 4.8 x 10−4 | 0.053, 0.078 |
CLOvsCLP (blood) | Chr8:124194847-124195193 | FAM83A | 5 | 1.3 x 10−3 | −0.072, −0.007 |
CLOvsCLP (blood) | Chr6:33280052-33280437 | TAPBP | 11 | 2.8 x 10−5 | −0.049, −0.008 |
CLOvsCLP (blood) | Chr7:4832112-4832536 | Intergenic [KIAA0415] | 5 | 8.6 x 10−4 | 0.023, 0.059 |
CPOvsCLP (blood) | Chr22:46508451-46508605 | MIRLET7A3 | 6 | 8.07 x 10−7 | 0.028, 0.119 |
CPOvsCLP (blood) | Chr17:80541737-80542119 | FOXK2 | 4 | 1.05 x 10−6 | 0.060, 0.079 |
CPOvsCLP (blood) | Chr10:101282726-101283091 | Intergenic [DQ372722] | 5 | 7.23 x 10−7 | 0.026, 0.077 |
CPOvsCLP (blood) | Chr16:55866757-55867073 | CES1 | 5 | 9.67 x 10−5 | −0.093, −0.066 |
CPOvsCLP (blood) | Chr22:51016501-51017152 | CPT1B | 12 | 1.47 x 10−7 | −0.063, −0.026 |
CPOvsCLO (blood) | Chr22:19709548-19710164 | GP1BB | 5 | 1.23 x 10−14 | 0.067, 0.162 |
CPOvsCLO (blood) | Chr22:46508451-46508605 | MIRLET7A3 | 6 | 1.51 x 10−14 | 0.035, 0.142 |
CPOvsCLO (blood) | Chr7:101398152-101398185 | Intergenic [CUX1] | 3 | 3.00 x 10−13 | −0.131, −0.085 |
CPOvsCLO (blood) | Chr1:212688417-212688998 | Intergenic [ATF3] | 6 | 1.23 x 10−16 | 0.018, 0.108 |
CPOvsCLO (blood) | Chr7:90895894-90896702 | FZD1 | 4 | 1.07 x 10−9 | 0.114, 0.170 |
CLOvsCLP (lip) | Chr7:158789723-158790116 | LOC154822 | 4 | 4.3 x 10−3 | −0.084, −0.045 |
CLOvsCLP (lip) | Chr6:161796785-161796855 | PARK2 | 3 | 1.4 x 10−2 | −0.073, −0.050 |
CLOvsCLP (lip) | Chr1:248100183-248100615 | OR2L13 | 10 | 4.1 x 10−5 | 0.027, 0.087 |
CLOvsCLP (lip) | Chr7:4832112-4832536 | KIAA0415 | 5 | 5.8 x 10−4 | −0.029, 0.043 |
CLOvsCLP (lip) | Chr1:7842159-7842407 | VAMP3 | 4 | 1.8 x 10−4 | −0.027, −0.055 |