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Table 3 Top five DMRs with the largest regression coefficients and Sidak-corrected P values <0.05

From: Distinct DNA methylation profiles in subtypes of orofacial cleft

EWAS DMR Genea N CpGs Sidak-corrected P value Range of regression coefficients
CLOvsCLP (blood) Chr6:160241105-160241557 PNLDC1 4 4.8 x 10−4 0.053, 0.078
CLOvsCLP (blood) Chr8:124194847-124195193 FAM83A 5 1.3 x 10−3 −0.072, −0.007
CLOvsCLP (blood) Chr6:33280052-33280437 TAPBP 11 2.8 x 10−5 −0.049, −0.008
CLOvsCLP (blood) Chr7:4832112-4832536 Intergenic [KIAA0415] 5 8.6 x 10−4 0.023, 0.059
CPOvsCLP (blood) Chr22:46508451-46508605 MIRLET7A3 6 8.07 x 10−7 0.028, 0.119
CPOvsCLP (blood) Chr17:80541737-80542119 FOXK2 4 1.05 x 10−6 0.060, 0.079
CPOvsCLP (blood) Chr10:101282726-101283091 Intergenic [DQ372722] 5 7.23 x 10−7 0.026, 0.077
CPOvsCLP (blood) Chr16:55866757-55867073 CES1 5 9.67 x 10−5 −0.093, −0.066
CPOvsCLP (blood) Chr22:51016501-51017152 CPT1B 12 1.47 x 10−7 −0.063, −0.026
CPOvsCLO (blood) Chr22:19709548-19710164 GP1BB 5 1.23 x 10−14 0.067, 0.162
CPOvsCLO (blood) Chr22:46508451-46508605 MIRLET7A3 6 1.51 x 10−14 0.035, 0.142
CPOvsCLO (blood) Chr7:101398152-101398185 Intergenic [CUX1] 3 3.00 x 10−13 −0.131, −0.085
CPOvsCLO (blood) Chr1:212688417-212688998 Intergenic [ATF3] 6 1.23 x 10−16 0.018, 0.108
CPOvsCLO (blood) Chr7:90895894-90896702 FZD1 4 1.07 x 10−9 0.114, 0.170
CLOvsCLP (lip) Chr7:158789723-158790116 LOC154822 4 4.3 x 10−3 −0.084, −0.045
CLOvsCLP (lip) Chr6:161796785-161796855 PARK2 3 1.4 x 10−2 −0.073, −0.050
CLOvsCLP (lip) Chr1:248100183-248100615 OR2L13 10 4.1 x 10−5 0.027, 0.087
CLOvsCLP (lip) Chr7:4832112-4832536 KIAA0415 5 5.8 x 10−4 −0.029, 0.043
CLOvsCLP (lip) Chr1:7842159-7842407 VAMP3 4 1.8 x 10−4 −0.027, −0.055
  1. aFor intergenic regions, the closest annotated gene is shown in square brackets.