Table 1 Participant characteristics
From: Distinct DNA methylation profiles in subtypes of orofacial cleft
|  | CLO (n = 49) | CLP (n = 49) | CPO (n = 49) | P value* |
|---|---|---|---|---|
Age in months at sample collection (95% CI) | 4.1 (3.8, 4.4) | 5.5 (4.7, 6.3) | 11.2 (10.3, 12.0) | 3.9 × 10−27 |
Epigenetic agea in months at sample collection (95% CI) | 5.4 (4.2, 6.5) | 8.7 (7.1, 10.3) | 13.7 (11.9, 15.5) | 5.0 × 10−11 |
Age accelerationb in months (95% CI) | −0.3 (−1.5, 0.8) | 0.8 (−0.1, 1.8) | −0.5 (−2.0, 1.0) | 0.23 |
Female (%) | 19 (39%) (1 missing) | 8 (16%) | 23 (47%) | 0.004 |
White ethnicity (%) | 25 (93%) (22 missing) | 27 (93%) (20 missing) | 23 (88%) (23 missing) | 0.80 |
Maternal age at conception (95% CI) | 30.9 (29.4, 32.4) | 29.4 (27.9, 30.9) | 31.1 (29.8, 32.4) | 0.21 |
Paternal age at conception (95% CI) | 34.1 (32.2, 35.9) | 32.7 (30.8, 34.7) | 35.3 (33.4, 37.1) | 0.23 |
Methylation-predicted tobacco exposure score (95% CI) | 0.004 (−0.1, 0.1) | −0.1 (−0.2, 0.1) | 0.1 (−0.1, 0.2) | 0.361 |
Self-reported maternal smoking around conception (%) | 0 (0%) (33 missing) | 4 (36%) (38 missing) | 7 (44%) (33 missing) | 0.01 |
Maternal education: university degree or higher (%) | 13 (48%) (22 missing) | 13 (48%) (22 missing) | 15 (58%) (23 missing) | 0.73 |
Maternal occupation: non-manual work | 10 (38%) (23 missing) | 13 (50%) (23 missing) | 14 (61%) (26 missing) | 0.29 |
Parity > =1 | 12 (43%) (21 missing) | 19 (66%) (20 missing) | 11 (46%) (25 missing) | 0.18 |