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Table 2 Effects of personal BC exposure on DNA promoter region methylation measured 5 days later: RR of methylation in the highest tertile vs the second and lowest (as reference)

From: Effect of personal exposure to black carbon on changes in allergic asthma gene methylation measured 5 days later in urban children: importance of allergic sensitization

   Overall effects, RR [95% CI]
Gene CpG promoter regiona Unadjusted Adjustedb
IL4 −326 0.82 [0.63–1.06] 0.82 [0.63–1.07]
  −48 0.75 [0.58–0.96]* 0.77 [0.61–0.97]*
IFNγ −186 1.15 [0.86–1.53] 1.18 [0.88–1.58]
  −54 0.91 [0.68–1.20] 0.92 [0.68–1.26]
NOS2A +5099 0.84 [0.64–1.09] 0.82 [0.65–1.03]
  +5106 1.20 [0.91–1.59] 1.21 [0.94–1.55]
ARG2 −32, −30, and −26c 1.06 [0.95–1.18] 1.04 [0.94–1.15]
  1. Note: 86 of the 143 children underwent repeat testing 6 months later allowing for n = 229 total observations analyzed
  2. * p value <0.05
  3. aCpG position relative to the transcriptional start site
  4. bAdjusted for race/ethnicity, sex, age, asthma diagnosis, obesity, seroatopy, heating season, and DNA methylation at day 1
  5. cAverage methylation of ARG2 CpG sites of −32, −30, and −26