Skip to main content

Table 2 Distribution of socio-demographic and clinical features in 9 OPSCC patients who recurred within 24 months from end of treatment (cases) and 24 OPSCC patients who did not (controls) who served as validation set

From: Prognostic significance of LINE-1 hypomethylation in oropharyngeal squamous cell carcinoma

Variable

Cases, n = 9

Controls, n = 24

p valuec

n

(%)

n

(%)

Gender

 Male

4

(44.4)

17

(70.8)

0.23

 Female

5

(55.6)

7

(29.2)

 

Age, years

 <55

1

(11.1)

4

(16.7)

1.00

 55–59

2

(22.2)

4

(16.7)

 

 ≥60

6

(66.7)

16

(66.7)

 

Smoking habits

 Never

3

(33.3)

5

(20.8)

0.32

 Former

1

(11.1)

1

(4.2)

 

 Current

5

(55.6)

18

(75.0)

 

Na, b

 0–1

3

(33.3)

9

(37.5)

1.00

 2–3

6

(66.7)

15

(62.5)

 

Ta, b

 1–2

3

(33.3)

8

(33.3)

1.00

 3–4

6

(66.7)

16

(66.7)

 

Stage

 III

2

(22.2)

6

(25.0)

1.00

 IV

7

(77.8)

18

(75.0)

 

HPV16

 Negative

8

(88.9)

12

(50.0)

0.06

 Positive

1

(11.1)

12

(50.0)

 

Therapy

 RT ± CT

3

(33.3)

12

(50.0)

0.46

 RT + CH ± CT

6

(66.7)

12

(50.0)

 
  1. aThe sum does not add up to total because of missing values
  2. b N number of lymph nodes involved, T tumor size, RT radiotherapy, CT chemotherapy, CH surgery
  3. cFisher’s exact test
  4. dStatistical comparison of the different characteristics in discovery and validation series