Epigenome-wide association of myocardial infarction with DNA methylation sites at loci related to cardiovascular disease

Table 3 Association analysis for SNPs and DNAm sites located in ZFHX3 and SMARCA4 for the control group

SNP	Chromosome	Position (bp)	Strand	Allele (minor/major)	MAF (%)	DNAm site	Effect ± SE	p
ZFHX3
rs7193343	16	73,029,160	+	C/T	40.4	cg07786668	−0.0011 ± 0.0011	0.307
						cg00614832	0.0004 ± 0.0013	0.755
rs2106261	16	73,051,620	+	T/C	33.1	cg07786668	−0.0016 ± 0.0011	0.176
						cg00614832	0.0004 ± 0.0014	0.774
rs879324	16	73,068,678	+	A/G	38.3	cg07786668	−0.0015 ± 0.0011	0.186
						cg00614832	0.0005 ± 0.0014	0.718
SMARCA4
rs3786725^a	19	11,166,827	+	A/G	11.2	cg17218495	0.0008 ± 0.0011	0.461

The Effect and p values were calculated with a GLM. The Effect value represents the change in β-value per minor allele copy for the SNP
^aThis SNP is in linkage disequilibrium with rs1122608 in SMARCA4 (r ² = 0.956 based on Asian samples of the 1000 Genomes Project phase I)

ISSN: 1868-7083