Epigenome-wide association of myocardial infarction with DNA methylation sites at loci related to cardiovascular disease

Table 2 Association analysis for MI and genome-wide significant DNAm sites

DNAm site	Chr	Position (bp)	Nearest gene	Relation to CpG island	Model 1		Model 2
DNAm site	Chr	Position (bp)	Nearest gene	Relation to CpG island	Effect ± SE	p	Effect ± SE	p
cg06642177	6	134,496,341	SGK1	CpG island	0.023 ± 0.004	4.33 × 10⁻⁸*	0.022 ± 0.004	7.47 × 10⁻⁷
cg07786668	16	73,092,391	ZFHX3	CpG island	0.018 ± 0.003	3.96 × 10⁻¹⁰*	0.016 ± 0.003	1.04 × 10⁻⁷*
cg17218495	19	11,071,743	SMARCA4	CpG island	0.015 ± 0.003	3.77 × 10⁻⁸*	0.015 ± 0.003	6.60 × 10⁻⁸*

The Effect and p values were calculated with a GLM, with the Effect values representing change in β value per change from control to case. The p values were corrected for genomic control
Chr chromosome
*Genome-wide significance (p < 1.43 × 10⁻⁷)

ISSN: 1868-7083