Fig. 3
From: Circulating nucleosomes as new blood-based biomarkers for detection of colorectal cancer
Discrimination of four NuQ® assay panels in an age-adjusted algorithm CRC, polyps, and healthy controls. The box plot shows significantly higher scores in patients with a CRC (n = 23) compared with healthy controls (n = 19) (p < 0.001) and between CRC patients (n = 23) and patients with polyps (n = 16) (p < 0.001). The score for each group was performed with pre-processed NuQ® ELISA data from four cf-nucleosome biomarkers: histone modifications H2AK119Ub, H3K9Ac, H3K27Ac, and the global level of nucleosome and age. Fisher’s linear discriminant model was used to calculate the score. p values were determined by Mann-Whitney rank-sum test. The box plot shows the median and the 25th and 75th percentiles; the whiskers indicate the 5th and the 95th percentiles. A.U. arbitrary unit