Fig. 1
From: Circulating nucleosomes as new blood-based biomarkers for detection of colorectal cancer
Combination of four cf-nucleosome biomarkers in CRC patients, patients with polyps, and healthy controls. Box plot demonstrating significantly higher score in patients with a CRC (n = 23) compared with healthy controls (n = 19) (p < 0.001) and between CRC patients (n = 23) and patients with polyps (n = 16) (p = 0.006). The score for each group was achieved with pre-processed NuQ® ELISA data from four cf-nucleosome biomarkers: histone modifications H2AK119Ub, H3K9Ac, H3K27Ac, and the global level of nucleosome. Fisher’s linear discriminant model was used to calculate the score. p values were determined by Mann-Whitney rank-sum test. The box plot shows the median and the 25th and 75th percentiles; the whiskers indicate the 5th and 95th percentiles. A.U. arbitrary unit