Table 3 Clinical variables of interest and CIMP concordance status
Variable | Metastasis − primary− (n = 64) | Metastasis − primary+ (n = 1) | Metastasis + primary− (n = 0) | Metastasis + primary+ (n = 5) | *P value | ||||
|---|---|---|---|---|---|---|---|---|---|
N | % | N | % | N | % | N | % | ||
Age | 0.52 | ||||||||
Mean (range) | 61.0 | [24.2, 79.9] | 74.4 | [74.4, 74.4] | 60.6 | [51.1, 66.8] | |||
Missing | 8 | 0 | 0 | 0 | |||||
Sex | 0.36 | ||||||||
Female | 30 | 50% | 1 | 100% | 1 | 20% | |||
Male | 30 | 50% | 0 | 0 | 4 | 80% | |||
Missing | 4 | 0 | 0 | 0 | |||||
Stage at diagnosis | >0.99 | ||||||||
I | 0 | 0 | 0 | 0 | 0 | 0 | |||
II | 6 | 11% | 0 | 0 | 0 | 0 | |||
III | 13 | 23% | 0 | 0 | 1 | 20% | |||
IV | 37 | 67% | 1 | 100% | 4 | 80% | |||
Missing | 7 | 0 | 0 | 0 | |||||
Primary site | >0.99 | ||||||||
Right | 12 | 21% | 0 | 0 | 1 | 20% | |||
Left | 45 | 79% | 1 | 100% | 4 | 80% | |||
Missing | 7 | 0 | 0 | 0 | |||||
Histological grade | 0.21 | ||||||||
Grade 1–2 | 35 | 66% | 1 | 100% | 5 | 100% | |||
Grade 3 | 18 | 34% | 0 | 0 | 0 | 0 | |||
Missing | 11 | 0 | 0 | 0 | |||||
Mucinous features | 0.10 | ||||||||
No | 45 | 82% | 1 | 100% | 2 | 40% | |||
Yes | 10 | 18% | 0 | 0 | 3 | 60% | |||
Missing | 9 | 0 | 0 | 0 | |||||
Lymphovascular invasion | >0.99 | ||||||||
No | 38 | 72% | 1 | 100% | 4 | 80% | |||
Yes | 15 | 28% | 0 | 0 | 1 | 20% | |||
Missing | 11 | 0 | 0 | 0 | |||||
Perineural invasion | >0.99 | ||||||||
No | 40 | 71% | 1 | 100% | 4 | 80% | |||
Yes | 12 | 21% | 0 | 0 | 1 | 20% | |||
Not applicable | 4 | 7% | 0 | 0 | 0 | 0 | |||
Missing | 8 | 0 | 0 | 0 | |||||
Molecular status, mutant | |||||||||
KRAS | 22 | 37% | 1 | 100% | 0 | 1 | 20% | 0.33 | |
BRAF | 2 | 3% | 0 | 0 | 0 | 0 | 0 | >0.99 | |
NRAS | 2 | 3% | 0 | 0 | 0 | 0 | 0 | >0.99 | |
Mismatch repair status, deficienta | 0 | 0 | 0 | 0 | 0 | n/a | |||