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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Integrated data analysis reveals potential drivers and pathways disrupted by DNA methylation in papillary thyroid carcinomas

Fig. 1

Workflow representative of the strategy used in the integrative analyses and in the cross-study validation. a Genome-wide methylation analysis revealed 6070 differentially methylated probes, and large-scale gene expression analysis identified 1657 differentially expressed genes in PTC (the last from a previous study). Corresponding probes/genes were submitted to a Pearson correlation test (34 PTC analyzed by both platforms) revealing 214 genes presenting probes with negative correlation and 49 genes with positive correlation. A total of 247 genes were classified as potentially regulated by DNA methylation in PTC. b A total of 4563 differentially methylated probes and 333 differentially expressed genes were identified in PTC according to BRAFV600E mutation. The Pearson correlation test revealed 69 and 17 genes with negative and positive correlation, respectively. Eighty three genes were classified as potentially regulated by DNA methylation in PTC BRAF mutated. *Tumor samples were initially corrected by NT samples (∆βPTC-∆βNT) and then BRAF positive and negative tumors were compared; §Some genes presented both methylation probes negatively and positively correlated. #Unadjusted p value

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