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Table 5 Clinical and anthropometric data for individuals in the study

From: Genome-wide DNA methylation analysis reveals loci that distinguish different types of adipose tissue in obese individuals

Trait Before weight loss After weight loss P value (paired t test)
Discovery cohort, n = 15
 Gender Female (n = 15), male (n = 0)   
 Age (years) 44 (±10) 45 (±10)  
 Weight (kg) 123.9 (±33.32) 76.2 (±15.4) 6.9 × 10−9
 BMI (kg/m2) 47.6 (±11.3) 29.3 (±5.5) 3.0 × 10−7
 Glucose (mmol/L) 5.5 (±1.2) 4.6 (±0.6) 0.035
 Insulin (pmol/L) 176.2 (±168.1) 33.4 (±19.3) 0.011
 HbA1c % (DCCT)a 6.0 (±0.6) 5.5 (±0.5) 0.036
 Triglycerides (mmol/L) 1.6 (±0.7) 1.0 (±0.3) 0.01
 Total cholesterol (mmol/L) 5.3 (±0.8) 4.6 (±0.6) 9.0 × 10−4
 HDL (mmol/L) 1.4 (±0.4) 1.8 (±±0.9) 0.167
 LDL (mmol/L) 3.2 (±1.1) 2.6 (±0.6) 0.018
 Systolic blood pressure (mmHg) 135 (±18) 115 (±9) 0.006
 Diastolic blood pressure (mmHg) 78 (±13) 73 (±9) 0.122
 Time (months)   17.6 (±6.9)  
In-house validation cohort, n = 15b
 Gender Female (n = 6), male (n = 9)   
 Age (years) Female 45 (±6) Female 47 (±6)  
Male 47 (±10) Male 49 (±10)
 Weight (kg) Female 118.7 (±13.9) Female 77.5 (±9.7) 1.9 × 10−4
Male 156.2 (±17.3) Male 95.8 (±12.4) 3.7 × 10−5
 BMI (kg/m2) Female 43.8 (±4.0) Female 28.9 (±2.9) 2.1 × 10−4
Male 50.3 (±7.6) Male 30.7 (±2.6) 1.0 × 10−4
 Glucose (mmol/L) Female 5.8 (±1.8) Female 4.7 (±0.4) 0.169
Male 5.8 (±0.9) Male 5.0 (±0.5) 0.038
 Insulin (pmol/L) Female 69.7 (±39.7) Female 25.2 (±17.1) 0.017
Male 184.0 (±72.0) Male 49.5 (±29.6) 0.013
 HbA1c % (DCCT)a Female 6.4 (±1.6) Female 5.5 (±0.6) 0.148
Male 6.2 (±0.5) Male 5.5 (±0.4) 0.163
 Triglycerides (mmol/L) Female 1.3 (±1.0) Female 0.8 (±0.3) 0.121
Male 1.7 (±1.0) Male 1.2 (±0.3) 0.039
 Total cholesterol (mmol/L) Female 4.6 (±1.0) Female 4.9 (±1.5) 0.677
Male 5.0 (±1.1) Male 4.3 (±4.3) 0.092
 HDL (mmol/L) Female 1.4 (±0.2) Female 1.5 (±0.2) 0.042
Male 1.1 (±0.1) Male 1.5 (±0.4) 0.038
 LDL (mmol/L) Female 2.6 (±0.8) Female 3.0 (±1.4) 0.548
Male 3.1 (±0.9) Male 2.3 (±0.5) 0.055
 Systolic blood pressure (mmHg) Female 123 (±11) Female 112 (±13)  
Male 127 (±24) Male 121 (±14)
 Diastolic blood pressure (mmHg) Female 76 (±6) Female 69 (±11)  
Male 77 (±6) Male 74 (±12)
 Time (months)   Female 19.8 (±5.5)  
Male 17.4 (±6)
  1. Data are expressed as means ± standard deviation. Paired adipose samples were available for all 15 before weight loss and for 13/15 after weight loss
  2. aHbA1c is reported as % using DCCT (Diabetes Control and Complications Trial) units
  3. bBlood pressure data was not available for samples in the validation cohort
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Clinical Epigenetics

ISSN: 1868-7083

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