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Table 5 Clinical and anthropometric data for individuals in the study

From: Genome-wide DNA methylation analysis reveals loci that distinguish different types of adipose tissue in obese individuals

Trait

Before weight loss

After weight loss

P value (paired t test)

Discovery cohort, n = 15

 Gender

Female (n = 15), male (n = 0)

  

 Age (years)

44 (±10)

45 (±10)

 

 Weight (kg)

123.9 (±33.32)

76.2 (±15.4)

6.9 × 10−9

 BMI (kg/m2)

47.6 (±11.3)

29.3 (±5.5)

3.0 × 10−7

 Glucose (mmol/L)

5.5 (±1.2)

4.6 (±0.6)

0.035

 Insulin (pmol/L)

176.2 (±168.1)

33.4 (±19.3)

0.011

 HbA1c % (DCCT)a

6.0 (±0.6)

5.5 (±0.5)

0.036

 Triglycerides (mmol/L)

1.6 (±0.7)

1.0 (±0.3)

0.01

 Total cholesterol (mmol/L)

5.3 (±0.8)

4.6 (±0.6)

9.0 × 10−4

 HDL (mmol/L)

1.4 (±0.4)

1.8 (±±0.9)

0.167

 LDL (mmol/L)

3.2 (±1.1)

2.6 (±0.6)

0.018

 Systolic blood pressure (mmHg)

135 (±18)

115 (±9)

0.006

 Diastolic blood pressure (mmHg)

78 (±13)

73 (±9)

0.122

 Time (months)

 

17.6 (±6.9)

 

In-house validation cohort, n = 15b

 Gender

Female (n = 6), male (n = 9)

  

 Age (years)

Female 45 (±6)

Female 47 (±6)

 

Male 47 (±10)

Male 49 (±10)

 Weight (kg)

Female 118.7 (±13.9)

Female 77.5 (±9.7)

1.9 × 10−4

Male 156.2 (±17.3)

Male 95.8 (±12.4)

3.7 × 10−5

 BMI (kg/m2)

Female 43.8 (±4.0)

Female 28.9 (±2.9)

2.1 × 10−4

Male 50.3 (±7.6)

Male 30.7 (±2.6)

1.0 × 10−4

 Glucose (mmol/L)

Female 5.8 (±1.8)

Female 4.7 (±0.4)

0.169

Male 5.8 (±0.9)

Male 5.0 (±0.5)

0.038

 Insulin (pmol/L)

Female 69.7 (±39.7)

Female 25.2 (±17.1)

0.017

Male 184.0 (±72.0)

Male 49.5 (±29.6)

0.013

 HbA1c % (DCCT)a

Female 6.4 (±1.6)

Female 5.5 (±0.6)

0.148

Male 6.2 (±0.5)

Male 5.5 (±0.4)

0.163

 Triglycerides (mmol/L)

Female 1.3 (±1.0)

Female 0.8 (±0.3)

0.121

Male 1.7 (±1.0)

Male 1.2 (±0.3)

0.039

 Total cholesterol (mmol/L)

Female 4.6 (±1.0)

Female 4.9 (±1.5)

0.677

Male 5.0 (±1.1)

Male 4.3 (±4.3)

0.092

 HDL (mmol/L)

Female 1.4 (±0.2)

Female 1.5 (±0.2)

0.042

Male 1.1 (±0.1)

Male 1.5 (±0.4)

0.038

 LDL (mmol/L)

Female 2.6 (±0.8)

Female 3.0 (±1.4)

0.548

Male 3.1 (±0.9)

Male 2.3 (±0.5)

0.055

 Systolic blood pressure (mmHg)

Female 123 (±11)

Female 112 (±13)

 

Male 127 (±24)

Male 121 (±14)

 Diastolic blood pressure (mmHg)

Female 76 (±6)

Female 69 (±11)

 

Male 77 (±6)

Male 74 (±12)

 Time (months)

 

Female 19.8 (±5.5)

 

Male 17.4 (±6)

  1. Data are expressed as means ± standard deviation. Paired adipose samples were available for all 15 before weight loss and for 13/15 after weight loss
  2. aHbA1c is reported as % using DCCT (Diabetes Control and Complications Trial) units
  3. bBlood pressure data was not available for samples in the validation cohort
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Clinical Epigenetics

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