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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPD

Fig. 3

Dynamic changes of DNA methylation in the FOXA2 promoter during goblet cell differentiation of PBEC from control subjects. a Schematic representations of the promoter region of the FOXA2 gene, outlining the putative binding sites for transcription factors (STAT6, GFI, NKX2-1/NKX3-1, CTCF, SPDEF, and SP1) (MatInspector, top relevants). DNA methylation levels of six CpG sites in the promoter, which were part of a CpG island (indicated in the figure), were examined for the indicated areas. b PBEC from control subjects 1–6 (Table 1, n = 6) were cultured at ALI and DNA methylation levels were analyzed at four different time points. Data represent the connected median methylation levels (min to max) of different CpG sites at each time points

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