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Fig. 2 | Clinical Epigenetics

Fig. 2

From: 36 h fasting of young men influences adipose tissue DNA methylation of LEP and ADIPOQ in a birth weight-dependent manner

Fig. 2

Assay design. Overview of successfully analyzed CpG sites in LEP (a) and ADIPOQ (b) by EpiTYPER. For LEP, two EpiTYPER assays were designed to cover the proximal LEP promoter region (Assay 1 and Assay 2). For ADIPOQ, one assay was designed to cover the distal enhancer region (Assay 1) and one assay to cover a proximal promoter region (Assay 2). Due to base-specific cleavage, several CpG sites were analyzed as units, as indicated with brackets. The binding sites for transcription factor C/EBP (CCAAT-enhancer-binding protein) (−55 to −44) and the TATA box (−30 to −25) is marked on the LEP promoter (a)

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