Fig. 4

DNA methylation differences are seen in the mitochondrial genome between the cerebellum and cortex. RPKM values in the total cortex and cerebellum across the mitochondrial genome are shown in the top panel, with gene positions downloaded from GENCODE shown in the middle panel. For each 100 bp window, paired t tests were performed to compare the cortex to the cerebellum, with -log10 (p) shown in the bottom panel. BLD blood, BA8 Brodmann area 8, BA9 Brodmann area 9, BA10 Brodmann area 10, CER cerebellum, CTX cortex, ECX entorhinal cortex, RPKM reads per kilobase of transcript per million mapped reads, STG superior temporal gyrus. Red dashed line denotes the Bonferroni significance, whilst blue dashed line denotes p < 0.05 in the lower panel