DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD

Clinical Epigenetics

Table 4 Top 10 differentially methylated CpG sites in COPD compared to smokers, sorted by P value

CpG site	Gene symbol	Chromosome	^aProbe Type	P value	^bGene location of first annotated transcript	^cIsland location
cg06723525		10	II	8.96E-05		S_Shore
cg08236285	CSMD1	8	II	6.95E-05	Body
cg09749225		6	I	8.57E-05		Island
cg10154826	FAM8A1	6	II	9.94E-05	1^stExon	Island
cg12035144	LOC285830	6	II	7.28E-05	TSS1500	S_Shore
cg12384790		12	II	1.96E-05		N_Shelf
cg13835168		6	II	1.64E-05
cg23073974		2	II	5.27E-05
cg26781321		8	II	8.79E-05
cg27061576		15	II	2.28E-05

^aProbe type I or type II design specified on the assay
^bLocation relative to the first listed transcript
^cN_ and S_ denote the upstream and downstream end of the island region, respectively

ISSN: 1868-7083