Fig. 1
From: DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD
Manhattan plots showing distribution of possible differentially methylated CpG sites identified in this study across chromosomes. a Differential methylation analysis between smokers and non-smokers presented by chromosomal location (x axis). b Differential methylation analysis between COPD and non-smokers presented by chromosomal location (x axis). c Differential methylation analysis between COPD and smokers presented by chromosomal location (x axis). The y axis represents the negative log P value of their association. The genes marked in blue color are the once validated by pyrosequencing analysis. The black dotted horizontal line indicates the genome-wide significance threshold of P < 0.001. The top candidates in each pairwise comparison were selected by test statistics and unadjusted P values for comparisons (P < 0.001 is commonly used as a cutoff for relatively small unadjusted raw P value)