Clusterization in head and neck squamous carcinomas based on lncRNA expression: molecular and clinical correlates

Clinical Epigenetics

Table 1 Summary of significant associations with lncRNA simple clusters

lncRNA cluster	c1	c2	c3	c4	c5
HPV infection	Negative	Negative	Negative	Negative	Positive
Mutation ENRICHED	NSD1 TP53	TP53 KMT2D		CASP8 CDKN2A NOTCH1
Mutation DEPLETED	CASP8	NOTCH1	NSD1	KMT2D NSD1	TP53 CDKN2A FAT1
lncRNAs UP	91	275	9	13	245
PCGs UP	293	792	133	389	1485
PCGs DOWN	80	132	33	104	150
Age	Younger	Older
Tobacco	Smokers	Smokers
Tumor grade ENRICHED				G1, G2	G3, G4
Tumor grade DEPLETED		G1		G3	G1, G2
Anatomic location ENRICHED	Larynx	Larynx		Tongue	Tonsil
Anatomic location DEPLETED	Tonsil	Tongue Tonsil	Larynx Tonsil	Larynx Tonsil	Tongue Larynx

ISSN: 1868-7083