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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Aberrant DNA methylation in melanoma: biomarker and therapeutic opportunities

Fig. 3

Potential mechanisms of synergy between DNA methylation inhibitors with targeted therapies and immune-checkpoint therapy. Inhibition of DNMTs has been shown to increase expression of melanoma antigens such as NY-ESO-1, MAGE family genes, and SSX-2. Inhibition of methylation can lead to tumor suppressor (VHL, hMLH1, p16, PTEN) re-expression, decreased proliferative signaling, increased viral response through activation of interferon signaling, altered expression of immunocheckpoint receptors, and increased antigen processing

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