Fig. 1
From: Aberrant DNA methylation in melanoma: biomarker and therapeutic opportunities
Abnormal DNA methylation in melanoma disrupts microRNA expression. In melanocytes and nevi (left), normal DNA methylation patterns contribute to balanced pro-tumorigenic (shown in red) and antitumorigenic (shown in green) microRNA expression. In melanoma (right), aberrant DNA methylation causes expression changes leading to microRNA imbalance and abundance of pro-tumorigenic microRNAs. See text for specific microRNAs disrupted and their targets