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Fig. 8 | Clinical Epigenetics

Fig. 8

From: DNA methylation signatures for 2016 WHO classification subtypes of diffuse gliomas

Fig. 8

Validation of the 13 CpG methylation signatures of GBM IDH mutant versus WT in an independent validation dataset GSE36278. a Heat map of the 13 CpG discriminatory probes identified in PAM analysis in IDH mutant (n = 16) and WT (n = 61) GBM patient samples in the entire TCGA dataset. A dual color code was used where yellow indicates more methylation (hypermethylation) and blue indicates less methylation (hypomethylation). b PCA was performed using β (methylation) values of 13 PAM-identified CpG probes between IDH mutant (n = 16) and WT (n = 61) GBM patient samples in the entire TCGA dataset. A scatter plot is generated using the first two principal components for each sample. The color code of the samples is as indicated. c The detailed probabilities of 10-fold cross-validation for the samples of training set based on the β values of 13 CpG probes are shown. For each sample, its probability as IDH mutant (red color) and WT (green color) of GBM patient samples is shown and it was predicted by the PAM program as either GBM IDH mutant or WT based on which grade’s probability is higher. The original histological grade of the samples is shown on the top

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