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Table 2 Stratified analysis (boys and girls) of adjusted associations for leptin methylation at four CpG sites and for overall mean as outcome and the three obesity-related measures as primary predictors

From: Associations of LEP, CRH, ICAM-1, and LINE-1 methylation, measured in saliva, with waist circumference, body mass index, and percent body fat in mid-childhood

Predictor LEP methylation (dependent variable)
CpG-1 CpG-2 CpG-3 CpG-4 Mean
Boys
β (SE)
Girls
β (SE)
P § Boys
β (SE)
Girls
β (SE)
P Boys
β (SE)
Girls
β (SE)
P Boys
β (SE)
Girls
β (SE)
P Boys
β (SE)
Girls
β (SE)
P
BMI-z −0.765*
(0.334)
0.429
(0.371)
0.02 −0.341**
(0.146)
0.001
(0.162)
0.11 −0.651**
(0.210)
0.286
0.234
0.003 −1.058**
(0.364)
0.190
(0.405)
0.02 −0.704**
(0.225)
0.227
(0.250)
0.01
WC-z −1.064*
(0.429)
0.443
(0.456)
0.01 −0.515**
(0.187)
−0.079
(0.199)
0.10 −0.681*
(0.272)
0.341
(0.289)
0.01 −1.235**
(0.469)
0.273
(0.498)
0.03 −0.874**
(0.289)
0.245
(0.307)
0.01
PBF −0.089*
(0.036)
0.057
(0.039)
0.01 −0.036*
(0.016)
0.005
(0.017)
0.08 −0.062**
(0.022)
0.030
(0.025)
0.01 −0.102*
(0.039)
−0.009
(0.044)
0.11 −0.072**
(0.024)
0.021
(0.027)
0.01
  1. Ordinary least squares regression models were adjusted for age and parental BMI
  2. BMI-z body mass index z-score, WC-z waist circumference z-score, PBF percent body fat
  3. P values: **0.001 ≤ P < 0.01; *0.01 ≤ P < 0.05
  4. § P value for interaction term between leptin methylation and sex