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Table 2 Stratified analysis (boys and girls) of adjusted associations for leptin methylation at four CpG sites and for overall mean as outcome and the three obesity-related measures as primary predictors

From: Associations of LEP, CRH, ICAM-1, and LINE-1 methylation, measured in saliva, with waist circumference, body mass index, and percent body fat in mid-childhood

Predictor

LEP methylation (dependent variable)

CpG-1

CpG-2

CpG-3

CpG-4

Mean

Boys

β (SE)

Girls

β (SE)

P §

Boys

β (SE)

Girls

β (SE)

P

Boys

β (SE)

Girls

β (SE)

P

Boys

β (SE)

Girls

β (SE)

P

Boys

β (SE)

Girls

β (SE)

P

BMI-z

−0.765*

(0.334)

0.429

(0.371)

0.02

−0.341**

(0.146)

0.001

(0.162)

0.11

−0.651**

(0.210)

0.286

0.234

0.003

−1.058**

(0.364)

0.190

(0.405)

0.02

−0.704**

(0.225)

0.227

(0.250)

0.01

WC-z

−1.064*

(0.429)

0.443

(0.456)

0.01

−0.515**

(0.187)

−0.079

(0.199)

0.10

−0.681*

(0.272)

0.341

(0.289)

0.01

−1.235**

(0.469)

0.273

(0.498)

0.03

−0.874**

(0.289)

0.245

(0.307)

0.01

PBF

−0.089*

(0.036)

0.057

(0.039)

0.01

−0.036*

(0.016)

0.005

(0.017)

0.08

−0.062**

(0.022)

0.030

(0.025)

0.01

−0.102*

(0.039)

−0.009

(0.044)

0.11

−0.072**

(0.024)

0.021

(0.027)

0.01

  1. Ordinary least squares regression models were adjusted for age and parental BMI
  2. BMI-z body mass index z-score, WC-z waist circumference z-score, PBF percent body fat
  3. P values: **0.001 ≤ P < 0.01; *0.01 ≤ P < 0.05
  4. § P value for interaction term between leptin methylation and sex