Table 1 Distribution of clinicopathological features in primary colorectal carcinomas, including distribution among genotypes of rs1800734
Feature | All Genotypes | GG | GA | AA |
|---|---|---|---|---|
N (%) | N (%) | N (%) | N (%) | |
Cases of primary colorectal carcinoma | 349 | 211 (60.5) | 119 (34.1) | 19 (5.4) |
Mean age (±SD) | 61.9 (8.8) | 62.0 (9.1) | 62.0 (8.4) | 60.8 (8.1) |
Sex | ||||
 Female | 163 (46.7) | 95 (45.0) | 58 (48.7) | 11 (57.9) |
 Male | 186 (53.3) | 116 (55.0) | 61 (51.3) | 8 (42.1) |
TNM stage | ||||
 1 | 22 (6.3) | 15 (7.1) | 6 (5.0) | 1 (5.3) |
 2 | 81 (23.2) | 52 (24.6) | 27 (22.7) | 2 (10.5) |
 3 | 208 (59.6) | 125 (59.2) | 70 (58.8) | 13 (68.4) |
 4 | 21 (6.0) | 12 (5.7) | 8 (6.7) | 1 (5.3) |
 Unavailable | 17 (4.9) | 7 (3.3) | 8 (6.7) | 2 (10.5) |
MSI status | ||||
 Stable/low | 287 (82.2) | 181 (85.8) | 95 (79.8) | 11 (57.9) |
 High | 62 (17.8) | 30 (14.2) | 24 (20.2) | 8 (42.1) |
MLH1 CpG island | ||||
 Unmethylated | 300 (86.0) | 187 (88.6) | 98 (82.3) | 15 (78.9) |
 Methylated | 34 (9.7) | 17 (8.1) | 14 (11.8) | 3 (15.8) |
 Unavailable | 15 (4.3) | 7 (3.3) | 7 (5.9) | 1 (5.3) |
MMR germline mutation | ||||
 No | 341 (97.7) | 209 (99.1) | 114 (95.8) | 18 (94.7) |
 Yes | 8 (2.3) | 2 (0.9) | 5 (4.2) | 1 (5.3) |