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Table 1 Distribution of clinicopathological features in primary colorectal carcinomas, including distribution among genotypes of rs1800734

From: The dynamic DNA methylation landscape of the mutL homolog 1 shore is altered by MLH1-93G>A polymorphism in normal tissues and colorectal cancer

Feature All Genotypes GG GA AA
N (%) N (%) N (%) N (%)
Cases of primary colorectal carcinoma 349 211 (60.5) 119 (34.1) 19 (5.4)
Mean age (±SD) 61.9 (8.8) 62.0 (9.1) 62.0 (8.4) 60.8 (8.1)
Sex
 Female 163 (46.7) 95 (45.0) 58 (48.7) 11 (57.9)
 Male 186 (53.3) 116 (55.0) 61 (51.3) 8 (42.1)
TNM stage
 1 22 (6.3) 15 (7.1) 6 (5.0) 1 (5.3)
 2 81 (23.2) 52 (24.6) 27 (22.7) 2 (10.5)
 3 208 (59.6) 125 (59.2) 70 (58.8) 13 (68.4)
 4 21 (6.0) 12 (5.7) 8 (6.7) 1 (5.3)
 Unavailable 17 (4.9) 7 (3.3) 8 (6.7) 2 (10.5)
MSI status
 Stable/low 287 (82.2) 181 (85.8) 95 (79.8) 11 (57.9)
 High 62 (17.8) 30 (14.2) 24 (20.2) 8 (42.1)
MLH1 CpG island
 Unmethylated 300 (86.0) 187 (88.6) 98 (82.3) 15 (78.9)
 Methylated 34 (9.7) 17 (8.1) 14 (11.8) 3 (15.8)
 Unavailable 15 (4.3) 7 (3.3) 7 (5.9) 1 (5.3)
MMR germline mutation
 No 341 (97.7) 209 (99.1) 114 (95.8) 18 (94.7)
 Yes 8 (2.3) 2 (0.9) 5 (4.2) 1 (5.3)
  1. Percentages may not add up to 100.0 due to rounding
  2. SD standard deviation