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Table 4 Associations between maternal choline intake during lactation (0–3 months after pregnancy and 3–6 months after pregnancy) and infant DNMT1, IGF2 DMR, RXRA, and LEP methylation in buccal epithelial cells

From: Maternal intake of methyl-group donors affects DNA methylation of metabolic genes in infants

Time point

0–3 months after pregnancy

3–6 months after pregnancy

Genea

B

(95% CI)

p value

N = 58

B

(95% CI)

p value

N = 42

DNMT1

0.080

(−0.062; 0.223)

0.2675

−0.060

(−0.360; 0.240)

0.6925

IGF2 DMR

−0.984

(−2.416; 0.449)

0.1764

0.479

(−2.157; 3.114)

0.7189

RXRA

0.291

(−0.057; 0.640)

0.1012

0.321

(−0.207; 0.850)

0.2319

LEP

−0.226

(−1.271; 0.818)

0.6695

0.057

(−1.713; 1.828)

0.9490

  1. β-Estimate is an absolute change in percentage of methylation; slope >(<) 0 means positive (negative) association
  2. aWhen there was no evidence for a differential association between maternal choline intake and DNA methylation at the different CpG locations, the main effect of maternal choline intake over all CpG locations was reported, which was the case for all genes
  3. CI confidence interval
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Clinical Epigenetics

ISSN: 1868-7083

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