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Table 3 Associations between maternal methyl-group donor intake (before and during pregnancy) and infant DNMT1, IGF2 DMR, RXRA, and LEP methylation in buccal epithelial cells

From: Maternal intake of methyl-group donors affects DNA methylation of metabolic genes in infants

Time point

Before pregnancy

First trimester

Second trimester

Third trimester

B

(95% CI)

p value

N = 21

B

(95% CI)

p value

N = 94

B

(95% CI)

p value

N = 85

B

(95% CI)

p value

N = 82

Gene

RXRA

All CpG sitesa

LEP

All CpG sitesa

IGF2 DMR

All CpG sitesa

IGF2 DMR

DNMT1

All CpG sitesa

DNMT1

All CpG sitesa

DNMT1

Nutrient

CpG1b

All CpG sitesa

CpG1b

CpG3b

Betaine

0.875

(0.118; 1.633)

0.0241

   

2.341

(−0.138; 4.82)

0.0640

    

Choline

     

−0.092

(−0.191; 0.008)

0.07

 

0.156

(0.029; 0.283)

0.0166

 

Folate

0.685

(0.245; 1.125)

0.0027

−1.233

(−2.342; −0.125)

0.0298

      

0.131

(0.016; 0.246)

0.0256

Folic acid

  

−0.706

(−1.242; −0.107)

0.0101

1.013

(−0.095; 2.121)

0.0728

 

−0.033

(−0.072; 0.006)

0.0987

−0.027

(−0.051; −0.004)

0.0204

  

Methionine

     

−0.013

(−0.029; 0.002)

0.0831

   
  1. β-Estimate is an absolute change in percentage of methylation; slope >(<) 0 means positive (negative) association
  2. aWhen there was no evidence for a differential association between maternal methyl-group donor intake and DNA methylation at the different CpG locations, the main effect of maternal methyl-group donor intake over all CpG locations was reported
  3. bWhen there was a significant interaction test, the association between maternal methyl-group donor intake and DNA methylation was different between CpG locations. In this case, the results were reported per CpG location
  4. CI confidence interval
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Clinical Epigenetics

ISSN: 1868-7083

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