Skip to main content

Table 3 Associations between maternal methyl-group donor intake (before and during pregnancy) and infant DNMT1, IGF2 DMR, RXRA, and LEP methylation in buccal epithelial cells

From: Maternal intake of methyl-group donors affects DNA methylation of metabolic genes in infants

Time point Before pregnancy First trimester Second trimester Third trimester
B
(95% CI)
p value
N = 21
B
(95% CI)
p value
N = 94
B
(95% CI)
p value
N = 85
B
(95% CI)
p value
N = 82
Gene RXRA
All CpG sitesa
LEP
All CpG sitesa
IGF2 DMR
All CpG sitesa
IGF2 DMR DNMT1
All CpG sitesa
DNMT1
All CpG sitesa
DNMT1
Nutrient
CpG1b All CpG sitesa CpG1b CpG3b
Betaine 0.875
(0.118; 1.633)
0.0241
    2.341
(−0.138; 4.82)
0.0640
    
Choline       −0.092
(−0.191; 0.008)
0.07
  0.156
(0.029; 0.283)
0.0166
 
Folate 0.685
(0.245; 1.125)
0.0027
−1.233
(−2.342; −0.125)
0.0298
       0.131
(0.016; 0.246)
0.0256
Folic acid    −0.706
(−1.242; −0.107)
0.0101
1.013
(−0.095; 2.121)
0.0728
  −0.033
(−0.072; 0.006)
0.0987
−0.027
(−0.051; −0.004)
0.0204
  
Methionine       −0.013
(−0.029; 0.002)
0.0831
   
  1. β-Estimate is an absolute change in percentage of methylation; slope >(<) 0 means positive (negative) association
  2. aWhen there was no evidence for a differential association between maternal methyl-group donor intake and DNA methylation at the different CpG locations, the main effect of maternal methyl-group donor intake over all CpG locations was reported
  3. bWhen there was a significant interaction test, the association between maternal methyl-group donor intake and DNA methylation was different between CpG locations. In this case, the results were reported per CpG location
  4. CI confidence interval