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Fig. 4 | Clinical Epigenetics

Fig. 4

From: An empirically driven data reduction method on the human 450K methylation array to remove tissue specific non-variable CpGs

Fig. 4

Multiple test corrected p values were lower in the filtered EWAS. a Volcano plot of the differential methylation analysis between smoking and non-smoking samples, with no filtering of non-variable CpGs. Vertical lines indicate a DNAm difference between 0.1. The horizontal line represents an FDR corrected p value of 0.05. Points are coloured to highlight CpGs exceeding both the biological and statistical cutoffs. Points with a black outline are CpGs found to be non-variable in blood. b Shown are the multiple test corrected p values (FDR) for the two CpGs of interest in AHRR. Lines connect FDR values between paired permutation sub-samples to show the trend between paired cohorts. The horizontal line shows the FDR values of 0.05

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