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Table 2 Luminometric methylation assay (LUMA)

From: Global DNA methylation levels are altered by modifiable clinical manipulations in assisted reproductive technologies

Criteria for comparison Groups (n) Global methylation fraction (mean ± SD) P value
ANOVA Tukey’s post hoc test (vs controls)
  Controls (77) 0.4827 ± 0.0723
Total ART ART (182) 0.5182 ± 0.0670 0.0002 a
Mode of egg fertilization ICSI (54) 0.5224 ± 0.0533 0.0009 < 0.01
Non ICSI (127) 0.5158 ± 0.0720 < 0.01
Oxygen tension 20%(123) 0.5176 ± 0.0689 0.0009 < 0.01
5%(59) 0.5195 ± 0.0634 < 0.01
Type of embryo transfer Fresh (128) 0.5109 ± 0.0684 < 0.0001 < 0.05
Frozen (54) 0.5357 ± 0.0608 < 0.0001
Embryo transfer day Day 3 (110) 0.5212 ± 0.0689 0.0007 < 0.001
Day 5 (72) 0.5138 ± 0.0643 < 0.05
  1. ANOVA analysis of variance; ART assisted reproductive technology; SD standard deviation; ICSI intracytoplasmic sperm injection
  2. aUnpaired two-tailed t test
  3. Values in italics denote significance