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Table 3 Univariate and multivariate Cox proportional hazard analysis of overall survival of HNSCC patients in the validation cohort from The Cancer Genome Atlas (n = 528)

From: PITX3 DNA methylation is an independent predictor of overall survival in patients with head and neck squamous cell carcinoma

 

Univariate

Multivariate

Variable

HR (95%CI)

p value

HR (95%CI)

p value

PITX3 methylation (dichotomized, optimized cut-off 35.1%)

1.43 (1.05–1.95)

0.022a

1.49 (1.02–2.16)

0.038a

N category

1.39 (1.14–1.70)

0.001a

1.25 (1.02–1.54)

0.035a

T category

1.31 (1.12–1.54)

0.001a

1.28 (1.06–1.56)

0.013a

  1. p16 expression was omitted from analysis due to largely missing data
  2. NA not analyzed
  3. asignificant feature