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Table 3 Univariate and multivariate Cox proportional hazard analysis of overall survival of HNSCC patients in the validation cohort from The Cancer Genome Atlas (n = 528)

From: PITX3 DNA methylation is an independent predictor of overall survival in patients with head and neck squamous cell carcinoma

  Univariate Multivariate
Variable HR (95%CI) p value HR (95%CI) p value
PITX3 methylation (dichotomized, optimized cut-off 35.1%) 1.43 (1.05–1.95) 0.022a 1.49 (1.02–2.16) 0.038a
N category 1.39 (1.14–1.70) 0.001a 1.25 (1.02–1.54) 0.035a
T category 1.31 (1.12–1.54) 0.001a 1.28 (1.06–1.56) 0.013a
  1. p16 expression was omitted from analysis due to largely missing data
  2. NA not analyzed
  3. asignificant feature