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Table 2 Univariate and multivariate Cox proportional hazard analysis of overall survival of HNSCC patients in the training cohort (n = 307)

From: PITX3 DNA methylation is an independent predictor of overall survival in patients with head and neck squamous cell carcinoma

  Univariate Multivariate
Variable HR (95%CI) p value HR (95%CI) p value
PITX3 methylation (dichotomized, optimized cut-off 72.5%) 1.80 (1.20–2.69) 0.005a 2.28 (1.29–4.00) 0.004a
p16 expression (neg. reference) 0.40 (0.20–0.81) 0.010a 0.27 (0.11–0.67) 0.005a
N category 1.28 (1.07–1.53) 0.008a 1.27 (0.97–1.67) 0.82
T category 1.14 (0.96–1.36) 0.14 1.33 (1.03–1.72) 0.029a
  1. Nineteen patients from the 326 patients of the cohort were omitted from survival analysis due to missing follow-up data
  2. NA not analyzed
  3. asignificant feature