Table 1 Probes with significant differential DNA methylation status between PD and control
From: Epigenome-wide association study of DNA methylation in panic disorder
CHR | Position (hg19) | Target ID | Mean β value | Mean Adjusted M value | Genes | Location with respect to genes | Relation to CpG Islada | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
PD | Control | PD | Control | P value | q value | ||||||
17 | 81037414 | cg25270498 | 0.257 | 0.283 | -1.71 | -1.53 | 5.67×10-10 | 1.19×10-4 | METRNL | TSS200 | Island |
19 | 36248877 | cg05910615 | 0.222 | 0.251 | -2.05 | -1.81 | 6.30×10-10 | 1.19×10-4 | HSPB6;C19orf55 | TSS1500;TSS200 | N_Shore |
2 | 122407145 | cg20340149 | 0.152 | 0.175 | -2.73 | -2.49 | 6.88×10-9 | 8.64×10-4 | CLASP1 | TSS200 | Island |
13 | 80055594 | cg14777817 | 0.134 | 0.153 | -2.90 | -2.69 | 5.17×10-8 | 4.87×10-3 | NDFIP2 | 1stExon | Island |
10 | 135088451 | cg25526061 | 0.147 | 0.164 | -2.79 | -2.56 | 1.30×10-7 | 7.64×10-3 | ADAM8 | Body | N_Shore |
17 | 27224823 | cg04266864 | 0.133 | 0.151 | -2.97 | -2.73 | 1.42×10-7 | 7.64×10-3 | FLOT2;DHRS13 | TSS200;3'UTR | Island |
16 | 12142335 | cg10475689 | 0.606 | 0.576 | 0.82 | 0.63 | 2.09×10-7 | 9.38×10-3 | RUNDC2A | Body | |
16 | 23568708 | cg05742564 | 0.192 | 0.215 | -2.30 | -2.08 | 2.48×10-7 | 9.38×10-3 | UBFD1;EARS2 | TSS200;TSS200 | Island |
1 | 228604037 | cg02931001 | 0.263 | 0.280 | -1.62 | -1.49 | 2.49×10-7 | 9.38×10-3 | TRIM17 | 5'UTR | Island |
13 | 28024472 | cg08209163 | 0.147 | 0.165 | -2.73 | -2.54 | 3.45×10-7 | 0.0118 | MTIF3 | TSS200;5'UTR | Island |
12 | 50017361 | cg10727759 | 0.147 | 0.165 | -2.74 | -2.54 | 4.51×10-7 | 0.0139 | PRPF40B | TSS200 | Island |
22 | 24236284 | cg12738349 | 0.290 | 0.304 | -1.40 | -1.30 | 4.80×10-7 | 0.0139 | MIF | TSS1500 | Island |
3 | 197409980 | cg08942682 | 0.830 | 0.848 | 2.06 | 2.28 | 6.05×10-7 | 0.0163 | KIAA0226 | Body | |
6 | 170597377 | cg05228964 | 0.602 | 0.580 | 0.71 | 0.59 | 7.23×10-7 | 0.0172 | DLL1 | Body | Island |
12 | 4381997 | cg08553284 | 0.316 | 0.330 | -1.20 | -1.11 | 7.57×10-7 | 0.0172 | CCND2 | TSS1500 | Island |
1 | 155164676 | cg03425468 | 0.215 | 0.240 | -2.10 | -1.88 | 7.78×10-7 | 0.0172 | MIR92B | TSS1500 | Island |
22 | 38202626 | cg11029475 | 0.202 | 0.219 | -2.23 | -2.02 | 8.43×10-7 | 0.0176 | GCAT;H1F0;H1F0 | TSS1500;1stExon;3'UTR | N_Shore |
16 | 2732724 | cg02205746 | 0.295 | 0.311 | -1.36 | -1.26 | 9.40×10-7 | 0.0182 | KCTD5 | 1stExon | Island |
17 | 44270511 | cg10256219 | 0.116 | 0.103 | -2.71 | -2.93 | 9.64×10-7 | 0.0182 | Island | ||
3 | 50375496 | cg09386807 | 0.236 | 0.256 | -1.86 | -1.70 | 1.14×10-6 | 0.0204 | RASSF1 | TSS1500;Body;5'UTR | Island |
8 | 28243934 | cg13411962 | 0.168 | 0.181 | -2.46 | -2.31 | 1.25×10-6 | 0.0211 | ZNF395 | 5'UTR;1stExon | Island |
4 | 4861398 | cg01959412 | 0.325 | 0.339 | -1.17 | -1.07 | 1.29×10-6 | 0.0211 | MSX1 | 5'UTR;1stExon | Island |
11 | 61197477 | cg03342113 | 0.264 | 0.278 | -1.58 | -1.48 | 1.53×10-6 | 0.0230 | CPSF7;SDHAF2 | TSS200;TSS200 | Island |
17 | 42293627 | cg24247482 | 0.556 | 0.557 | 0.50 | 0.39 | 1.53×10-6 | 0.0230 | UBTF | Body | N_Shelf |
17 | 80189962 | cg17932802 | 0.358 | 0.366 | -0.92 | -0.85 | 1.65×10-6 | 0.0239 | SLC16A3 | TSS200;5'UTR | Island |
1 | 204159498 | cg13065121 | 0.233 | 0.250 | -1.89 | -1.73 | 1.84×10-6 | 0.0253 | KISS1 | 3'UTR | N_Shore |
6 | 32055370 | cg26997880 | 0.225 | 0.247 | -1.98 | -1.79 | 1.95×10-6 | 0.0253 | TNXB | Body | Island |
12 | 121148158 | cg19464320 | 0.123 | 0.107 | -2.58 | -2.83 | 2.26×10-6 | 0.0284 | UNC119B | 1stExon;5'UTR | N_Shore |
9 | 87284706 | cg13965062 | 0.230 | 0.243 | -1.85 | -1.75 | 2.39×10-6 | 0.0290 | NTRK2 | 5'UTR;1stExon | Island |
1 | 245316477 | cg07124903 | 0.102 | 0.088 | -2.88 | -3.14 | 2.47×10-6 | 0.0290 | N_Shore | ||
19 | 11074303 | cg08315613 | 0.574 | 0.570 | 0.59 | 0.48 | 2.54×10-6 | 0.0290 | SMARCA4 | 5'UTR | S_Shore |
2 | 242254519 | cg13009927 | 0.196 | 0.214 | -2.22 | -2.05 | 3.28×10-6 | 0.0353 | SEPT2;HDLBP | TSS1500;5'UTR | Island |
2 | 217559020 | cg03222971 | 0.233 | 0.251 | -1.90 | -1.73 | 3.42×10-6 | 0.0357 | IGFBP5 | Body | N_Shore |
1 | 206223719 | cg26795730 | 0.196 | 0.215 | -2.23 | -2.05 | 3.53×10-6 | 0.0357 | AVPR1B | TSS1500 | Island |
2 | 73144353 | cg15921587 | 0.302 | 0.318 | -1.33 | -1.21 | 3.69×10-6 | 0.0357 | EMX1 | TSS1500 | Island |
13 | 25621328 | cg18098400 | 0.132 | 0.150 | -2.96 | -2.74 | 3.83×10-6 | 0.0357 | Island | ||
15 | 66993412 | cg25048202 | 0.290 | 0.306 | -1.41 | -1.30 | 3.84×10-6 | 0.0357 | SMAD6 | TSS1500 | N_Shore |
2 | 27718181 | cg04015759 | 0.250 | 0.267 | -1.71 | -1.58 | 3.89×10-6 | 0.0357 | FNDC4 | TSS200 | Island |
15 | 101690195 | cg24378951 | 0.753 | 0.728 | 1.80 | 1.61 | 4.53×10-6 | 0.0406 | |||
2 | 44059266 | cg15889012 | 0.194 | 0.213 | -2.25 | -2.07 | 4.74×10-6 | 0.0415 | ABCG5 | Body | S_Shore |