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Table 1 Probes with significant differential DNA methylation status between PD and control

From: Epigenome-wide association study of DNA methylation in panic disorder

CHR Position (hg19) Target ID Mean β value Mean Adjusted M value    Genes Location with respect to genes Relation to CpG Islada
PD Control PD Control P value q value
17 81037414 cg25270498 0.257 0.283 -1.71 -1.53 5.67×10-10 1.19×10-4 METRNL TSS200 Island
19 36248877 cg05910615 0.222 0.251 -2.05 -1.81 6.30×10-10 1.19×10-4 HSPB6;C19orf55 TSS1500;TSS200 N_Shore
2 122407145 cg20340149 0.152 0.175 -2.73 -2.49 6.88×10-9 8.64×10-4 CLASP1 TSS200 Island
13 80055594 cg14777817 0.134 0.153 -2.90 -2.69 5.17×10-8 4.87×10-3 NDFIP2 1stExon Island
10 135088451 cg25526061 0.147 0.164 -2.79 -2.56 1.30×10-7 7.64×10-3 ADAM8 Body N_Shore
17 27224823 cg04266864 0.133 0.151 -2.97 -2.73 1.42×10-7 7.64×10-3 FLOT2;DHRS13 TSS200;3'UTR Island
16 12142335 cg10475689 0.606 0.576 0.82 0.63 2.09×10-7 9.38×10-3 RUNDC2A Body  
16 23568708 cg05742564 0.192 0.215 -2.30 -2.08 2.48×10-7 9.38×10-3 UBFD1;EARS2 TSS200;TSS200 Island
1 228604037 cg02931001 0.263 0.280 -1.62 -1.49 2.49×10-7 9.38×10-3 TRIM17 5'UTR Island
13 28024472 cg08209163 0.147 0.165 -2.73 -2.54 3.45×10-7 0.0118 MTIF3 TSS200;5'UTR Island
12 50017361 cg10727759 0.147 0.165 -2.74 -2.54 4.51×10-7 0.0139 PRPF40B TSS200 Island
22 24236284 cg12738349 0.290 0.304 -1.40 -1.30 4.80×10-7 0.0139 MIF TSS1500 Island
3 197409980 cg08942682 0.830 0.848 2.06 2.28 6.05×10-7 0.0163 KIAA0226 Body  
6 170597377 cg05228964 0.602 0.580 0.71 0.59 7.23×10-7 0.0172 DLL1 Body Island
12 4381997 cg08553284 0.316 0.330 -1.20 -1.11 7.57×10-7 0.0172 CCND2 TSS1500 Island
1 155164676 cg03425468 0.215 0.240 -2.10 -1.88 7.78×10-7 0.0172 MIR92B TSS1500 Island
22 38202626 cg11029475 0.202 0.219 -2.23 -2.02 8.43×10-7 0.0176 GCAT;H1F0;H1F0 TSS1500;1stExon;3'UTR N_Shore
16 2732724 cg02205746 0.295 0.311 -1.36 -1.26 9.40×10-7 0.0182 KCTD5 1stExon Island
17 44270511 cg10256219 0.116 0.103 -2.71 -2.93 9.64×10-7 0.0182    Island
3 50375496 cg09386807 0.236 0.256 -1.86 -1.70 1.14×10-6 0.0204 RASSF1 TSS1500;Body;5'UTR Island
8 28243934 cg13411962 0.168 0.181 -2.46 -2.31 1.25×10-6 0.0211 ZNF395 5'UTR;1stExon Island
4 4861398 cg01959412 0.325 0.339 -1.17 -1.07 1.29×10-6 0.0211 MSX1 5'UTR;1stExon Island
11 61197477 cg03342113 0.264 0.278 -1.58 -1.48 1.53×10-6 0.0230 CPSF7;SDHAF2 TSS200;TSS200 Island
17 42293627 cg24247482 0.556 0.557 0.50 0.39 1.53×10-6 0.0230 UBTF Body N_Shelf
17 80189962 cg17932802 0.358 0.366 -0.92 -0.85 1.65×10-6 0.0239 SLC16A3 TSS200;5'UTR Island
1 204159498 cg13065121 0.233 0.250 -1.89 -1.73 1.84×10-6 0.0253 KISS1 3'UTR N_Shore
6 32055370 cg26997880 0.225 0.247 -1.98 -1.79 1.95×10-6 0.0253 TNXB Body Island
12 121148158 cg19464320 0.123 0.107 -2.58 -2.83 2.26×10-6 0.0284 UNC119B 1stExon;5'UTR N_Shore
9 87284706 cg13965062 0.230 0.243 -1.85 -1.75 2.39×10-6 0.0290 NTRK2 5'UTR;1stExon Island
1 245316477 cg07124903 0.102 0.088 -2.88 -3.14 2.47×10-6 0.0290    N_Shore
19 11074303 cg08315613 0.574 0.570 0.59 0.48 2.54×10-6 0.0290 SMARCA4 5'UTR S_Shore
2 242254519 cg13009927 0.196 0.214 -2.22 -2.05 3.28×10-6 0.0353 SEPT2;HDLBP TSS1500;5'UTR Island
2 217559020 cg03222971 0.233 0.251 -1.90 -1.73 3.42×10-6 0.0357 IGFBP5 Body N_Shore
1 206223719 cg26795730 0.196 0.215 -2.23 -2.05 3.53×10-6 0.0357 AVPR1B TSS1500 Island
2 73144353 cg15921587 0.302 0.318 -1.33 -1.21 3.69×10-6 0.0357 EMX1 TSS1500 Island
13 25621328 cg18098400 0.132 0.150 -2.96 -2.74 3.83×10-6 0.0357    Island
15 66993412 cg25048202 0.290 0.306 -1.41 -1.30 3.84×10-6 0.0357 SMAD6 TSS1500 N_Shore
2 27718181 cg04015759 0.250 0.267 -1.71 -1.58 3.89×10-6 0.0357 FNDC4 TSS200 Island
15 101690195 cg24378951 0.753 0.728 1.80 1.61 4.53×10-6 0.0406    
2 44059266 cg15889012 0.194 0.213 -2.25 -2.07 4.74×10-6 0.0415 ABCG5 Body S_Shore
  1. Abbreviation: CHR chromosome
  2. TSS, transcription start site
  3. UTR, untranslated region
  4. a Each category of “Relation to CpG island” column defines the following regions: Island, CpG island; N_Shore, 0-2 kb upstream of CpG island; S_Shore, 0-2 kb downstream of CpG island; N_Shelf, 2–4 kb upstream of CpG island