Skip to main content

Table 2 Epigenome-wide associations between genome-wide DNA methylation and lipid levels

From: Epigenome-wide association study (EWAS) on lipids: the Rotterdam Study

    

Discovery

Replication

 
 

CpG site

Chromosome

Position

Regression coefficient

p a

Regression coefficient

p a

Gene

Triglycerides

cg00574958

11

68607622

−0.0206

1.23 × 10 −15

−0.0114

7.24 × 10 −13

CPT1A

 

cg06500161

21

43656587

0.0149

5.02 × 10 −11

0.0201

1.46 × 10 −15

ABCG1

 

cg11024682

17

17730094

0.0135

3.40 × 10 −10

0.0172

3.27 × 10 −11

SREBF1

 

cg17901584

1

55353706

−0.0162

1.56 × 10 −08

−0.0068

9.54 × 10−02

DHCR24

 

cg17058475

11

68607737

−0.0183

9.84 × 10 −08

−0.0118

1.71 × 10 −06

CPT1A

HDL-C

cg06500161

21

43656587

−0.0202

1.84 × 10 −12

−0.0189

3.29 × 10 −12

ABCG1

 

cg14816825

11

12128203

−0.0143

6.31 × 10 −08

−0.0051

1.15 × 10−01

NA b

 

cg17901584

1

55353706

0.0196

6.44 × 10 −08

0.0142

1.03 × 10 −03

DHCR24

  1. Models are adjusted for age, gender, current smoking, leukocyte proportions, array number, and position on array
  2. Values are regression coefficients based on linear mixed models and reflect differences in methylation beta values per increase in HDL-C or log-transformed triglyceride unit
  3. a P values in italic indicate statistical significance. Level of significance: p < 1.08 × 10−07(discovery cohort), p < 7.14 × 10−03(replication)
  4. bNot annotated