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Table 2 Epigenome-wide associations between genome-wide DNA methylation and lipid levels

From: Epigenome-wide association study (EWAS) on lipids: the Rotterdam Study

     Discovery Replication  
  CpG site Chromosome Position Regression coefficient p a Regression coefficient p a Gene
Triglycerides cg00574958 11 68607622 −0.0206 1.23 × 10 −15 −0.0114 7.24 × 10 −13 CPT1A
  cg06500161 21 43656587 0.0149 5.02 × 10 −11 0.0201 1.46 × 10 −15 ABCG1
  cg11024682 17 17730094 0.0135 3.40 × 10 −10 0.0172 3.27 × 10 −11 SREBF1
  cg17901584 1 55353706 −0.0162 1.56 × 10 −08 −0.0068 9.54 × 10−02 DHCR24
  cg17058475 11 68607737 −0.0183 9.84 × 10 −08 −0.0118 1.71 × 10 −06 CPT1A
HDL-C cg06500161 21 43656587 −0.0202 1.84 × 10 −12 −0.0189 3.29 × 10 −12 ABCG1
  cg14816825 11 12128203 −0.0143 6.31 × 10 −08 −0.0051 1.15 × 10−01 NA b
  cg17901584 1 55353706 0.0196 6.44 × 10 −08 0.0142 1.03 × 10 −03 DHCR24
  1. Models are adjusted for age, gender, current smoking, leukocyte proportions, array number, and position on array
  2. Values are regression coefficients based on linear mixed models and reflect differences in methylation beta values per increase in HDL-C or log-transformed triglyceride unit
  3. a P values in italic indicate statistical significance. Level of significance: p < 1.08 × 10−07(discovery cohort), p < 7.14 × 10−03(replication)
  4. bNot annotated