Table 1 Participant characteristics
From: Epigenome-wide association study (EWAS) on lipids: the Rotterdam Study
Discoverya | Replicationa | p valueb | |
|---|---|---|---|
N | 725 | 760 | |
Gender (male) | 336 (46%) | 324 (42%) | 0.14 |
Age (years) | 59.9 ± 8.2 | 67.7 (5.9) | <0.001 |
BMI (kg/m2) | 27.6 ± 4.6 | 27.8 (4.2) | 0.48 |
Obesity (BMI > 30) | 173 (24%) | 194 (26%) | 0.54 |
Waist circumference | 93.7 ± 12.8 | 94.4 ± 12.0 | 0.318 |
Current smoking (yes) | 197 (27%) | 79 (10%) | <0.001 |
Triglycerides (mmol/L) | 1.3 [0.9–1.8] | 1.3 [1.0–1.7] | 0.66 |
HDL-cholesterol (mmol/L) | 1.4 (0.41) | 1.5 (0.44) | <0.001 |
LDL-cholesterol (mmol/L) | 3.9 (1.00) | 3.7 (0.95) | 0.001 |
Total cholesterol (mmol/L) | 5.6 (1.07) | 5.5 (1.03) | 0.26 |
Lipid-lowering medication (yes) | 191 (26%) | 238 (31%) | <0.001 |
CHD | 42 (6%) | 61 (8%) | 0.003 |
DM | 72 (10%) | 94 (12%) | 0.13 |