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Table 1 Participant characteristics

From: Epigenome-wide association study (EWAS) on lipids: the Rotterdam Study

  Discoverya Replicationa p valueb
N 725 760  
Gender (male) 336 (46%) 324 (42%) 0.14
Age (years) 59.9 ± 8.2 67.7 (5.9) <0.001
BMI (kg/m2) 27.6 ± 4.6 27.8 (4.2) 0.48
Obesity (BMI > 30) 173 (24%) 194 (26%) 0.54
Waist circumference 93.7 ± 12.8 94.4 ± 12.0 0.318
Current smoking (yes) 197 (27%) 79 (10%) <0.001
Triglycerides (mmol/L) 1.3 [0.9–1.8] 1.3 [1.0–1.7] 0.66
HDL-cholesterol (mmol/L) 1.4 (0.41) 1.5 (0.44) <0.001
LDL-cholesterol (mmol/L) 3.9 (1.00) 3.7 (0.95) 0.001
Total cholesterol (mmol/L) 5.6 (1.07) 5.5 (1.03) 0.26
Lipid-lowering medication (yes) 191 (26%) 238 (31%) <0.001
CHD 42 (6%) 61 (8%) 0.003
DM 72 (10%) 94 (12%) 0.13
  1. aValues are presented as mean ± SD, median [IQR], or N (%)
  2. bCharacteristics of the discovery cohort and replication cohort were compared with ANOVA