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Table 5 Association between age acceleration and WMH categories

From: Cerebral white matter hyperintensities on MRI and acceleration of epigenetic aging: the atherosclerosis risk in communities study

  

Horvath predictor

Hannum et al. predictor

  

OR (95% CI)

P value

P trend

OR (95% CI)

P value

P trend

Model 1

No WMH

1 (Ref)

 

0.08

1 (Ref)

 

0.08

Low WMH burden

1.01 (0.98–1.05)

0.40

1.03 (0.99–1.01)

0.10

High WMH burden

1.08 (1.01–1.17)

0.03

1.12 (1.04–1.21)

0.002

Model 2

No WMH

1 (Ref)

 

0.03

1 (Ref)

 

0.02

Low WMH burden

1.01 (0.98–1.05)

0.44

1.02 (0.99–1.06)

0.20

High WMH burden

1.11 (1.02–1.20)

0.01

1.15 (1.03–1.21)

0.007

Model 3

No WMH

1 (Ref)

 

0.06

1 (Ref)

 

0.07

Low WMH burden

1.02 (0.98–1.05)

0.33

1.03 (0.99–1.08)

0.13

High WMH burden

1.11 (1.02–1.20)

0.02

1.11 (1.01–1.21)

0.03

  1. No WMH (grade 0), N = 134; low WMH (grades 1–4), N = 546; high WMH (grades > =5), N = 33. Model 1: adjusted for age at brain MRI and sex. Model 2: adjusted for age at brain MRI, sex, body mass index, systolic blood pressure, hypertension, diabetes, and current smoking. Model 3: adjusted for covariates in model 2 and white blood cell composition
  2. OR odds ratio, 95% CI 95% confidence interval, Ref reference, P trend P value of test for trend
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Clinical Epigenetics

ISSN: 1868-7083

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