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Table 5 Association between age acceleration and WMH categories

From: Cerebral white matter hyperintensities on MRI and acceleration of epigenetic aging: the atherosclerosis risk in communities study

   Horvath predictor Hannum et al. predictor
   OR (95% CI) P value P trend OR (95% CI) P value P trend
Model 1 No WMH 1 (Ref)   0.08 1 (Ref)   0.08
Low WMH burden 1.01 (0.98–1.05) 0.40 1.03 (0.99–1.01) 0.10
High WMH burden 1.08 (1.01–1.17) 0.03 1.12 (1.04–1.21) 0.002
Model 2 No WMH 1 (Ref)   0.03 1 (Ref)   0.02
Low WMH burden 1.01 (0.98–1.05) 0.44 1.02 (0.99–1.06) 0.20
High WMH burden 1.11 (1.02–1.20) 0.01 1.15 (1.03–1.21) 0.007
Model 3 No WMH 1 (Ref)   0.06 1 (Ref)   0.07
Low WMH burden 1.02 (0.98–1.05) 0.33 1.03 (0.99–1.08) 0.13
High WMH burden 1.11 (1.02–1.20) 0.02 1.11 (1.01–1.21) 0.03
  1. No WMH (grade 0), N = 134; low WMH (grades 1–4), N = 546; high WMH (grades > =5), N = 33. Model 1: adjusted for age at brain MRI and sex. Model 2: adjusted for age at brain MRI, sex, body mass index, systolic blood pressure, hypertension, diabetes, and current smoking. Model 3: adjusted for covariates in model 2 and white blood cell composition
  2. OR odds ratio, 95% CI 95% confidence interval, Ref reference, P trend P value of test for trend