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Table 3 Association of WMH burden with chronologic age or estimates of DNA methylation age

From: Cerebral white matter hyperintensities on MRI and acceleration of epigenetic aging: the atherosclerosis risk in communities study

  Model 1 Model 2 Model 3
  R 2 (%) P value R 2 (%) P value R 2 (%) P value
Chronologic agea 8.06 <0.0001 7.71 <0.0001 5.62 <0.0001
Horvath DNA methylation age 4.74 <0.0001 5.00 <0.0001 3.51 <0.0001
Hannum et al. DNA methylation age 7.84 <0.0001 6.86 <0.0001 4.72 <0.0001
  1. Model 1: adjusted for age at brain MRIa and sex. Model 2: adjusted for age at brain MRIa, sex, body mass index, systolic blood pressure, hypertension, diabetes, and current smoking. Model 3: adjusted for covariates in model 2 and white blood cell composition
  2. aModels estimating the association of chronologic age with WMH are not adjusted for age at brain MRI