Table 3 Association of WMH burden with chronologic age or estimates of DNA methylation age
Model 1 | Model 2 | Model 3 | ||||
|---|---|---|---|---|---|---|
R 2 (%) | P value | R 2 (%) | P value | R 2 (%) | P value | |
Chronologic agea | 8.06 | <0.0001 | 7.71 | <0.0001 | 5.62 | <0.0001 |
Horvath DNA methylation age | 4.74 | <0.0001 | 5.00 | <0.0001 | 3.51 | <0.0001 |
Hannum et al. DNA methylation age | 7.84 | <0.0001 | 6.86 | <0.0001 | 4.72 | <0.0001 |