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Table 2 CFTR and CF modifier genes

From: DNA methylation at modifier genes of lung disease severity is altered in cystic fibrosis

Gene symbol Gene name Genomic coordinatesa nb. CpGb Amplicon size (bp) Differentially methylated CpG sitesc
Blood NEC
ATF1 Activating transcription factor1 chr12:50,764,850-50,765,098 12 249   
CFTR Cystic fibrosis transmembrane conductance regulator chr7:117,479,627-117,479,759 10 133 1(−)  
DUOX2 Dual oxidase 2 chr15:45,114,541-45,114,722 11 182   
EDNRA Endothelin receptor type A chr4:147,480,957-47,481,216 21 260 2(–) 3(–) 4(–) 8(–) 9(–) 16(–) 5(+) 10(+)
ENaCγ Epithelial sodium channel chr16:23,182,420-23,182,665 23 246 2(–) 9(–) 11(+) 2(–) 6(+) 16(–)
GSTM1 Glutathione S-transferase mu 1 chr1:109,687,687-109,687,897 13 211   
GSTM3 Glutathione S-transferase mu 3 chr1:109,740,573-109,740,793 9 221 1(–) 3(–) 4(–) 5(–) 6(–) 7(–) 8(–) 4(–) 9(–)
HMOX1 Heme oxygenase 1 chr22:35,381,269-35,381,436 5 168 2(–) 3(–) 4(+) 5(–) 2(+)
IFRD1 Interferon-related developmental regulator 1 chr7:112,450,883-112,451,040 12 158   10(–)
MUC5AC Mucine 5 AC chr11:1,194,622-1,194,807 13 186 1(+) 10(+) 12(+) 13(–) 1(+) 3(+) 4(+) 5(–) 8(+) 10(+) 11(+) 12(+) 13(+)
TGFβ TGFβ1 Transforming growth factor chr19:41,353,542-41,353,740 19 199   10(–)
TLR2 Toll-like receptor 2 chr4:153,684,576-153,684,704 12 129 8(–)  
TLR5 Toll-like receptor 5 chr1:223,142,813-223,142,967 8 155 8(–)  
YY1 Yin-Yang 1 transcription factor chr14:100,240,497-100,240,751 26 255 8(–) 22(–)  
  1. aHuman Genome GRCh38/hg38 build
  2. bnb of CpG in the analyzed region
  3. cPosition of the CpG in the analyzed sequence. Plus signs mean hypermethylated and minus signs mean hypomethylated CpG in CF patients