Table 2 CFTR and CF modifier genes
From: DNA methylation at modifier genes of lung disease severity is altered in cystic fibrosis
Gene symbol | Gene name | Genomic coordinatesa | nb. CpGb | Amplicon size (bp) | Differentially methylated CpG sitesc | |
|---|---|---|---|---|---|---|
Blood | NEC | |||||
ATF1 | Activating transcription factor1 | chr12:50,764,850-50,765,098 | 12 | 249 | ||
CFTR | Cystic fibrosis transmembrane conductance regulator | chr7:117,479,627-117,479,759 | 10 | 133 | 1(−) | |
DUOX2 | Dual oxidase 2 | chr15:45,114,541-45,114,722 | 11 | 182 | ||
EDNRA | Endothelin receptor type A | chr4:147,480,957-47,481,216 | 21 | 260 | 2(–) 3(–) 4(–) 8(–) 9(–) 16(–) | 5(+) 10(+) |
ENaCγ | Epithelial sodium channel | chr16:23,182,420-23,182,665 | 23 | 246 | 2(–) 9(–) 11(+) | 2(–) 6(+) 16(–) |
GSTM1 | Glutathione S-transferase mu 1 | chr1:109,687,687-109,687,897 | 13 | 211 | ||
GSTM3 | Glutathione S-transferase mu 3 | chr1:109,740,573-109,740,793 | 9 | 221 | 1(–) 3(–) 4(–) 5(–) 6(–) 7(–) 8(–) | 4(–) 9(–) |
HMOX1 | Heme oxygenase 1 | chr22:35,381,269-35,381,436 | 5 | 168 | 2(–) 3(–) 4(+) 5(–) | 2(+) |
IFRD1 | Interferon-related developmental regulator 1 | chr7:112,450,883-112,451,040 | 12 | 158 | 10(–) | |
MUC5AC | Mucine 5 AC | chr11:1,194,622-1,194,807 | 13 | 186 | 1(+) 10(+) 12(+) 13(–) | 1(+) 3(+) 4(+) 5(–) 8(+) 10(+) 11(+) 12(+) 13(+) |
TGFβ | TGFβ1 Transforming growth factor | chr19:41,353,542-41,353,740 | 19 | 199 | 10(–) | |
TLR2 | Toll-like receptor 2 | chr4:153,684,576-153,684,704 | 12 | 129 | 8(–) | |
TLR5 | Toll-like receptor 5 | chr1:223,142,813-223,142,967 | 8 | 155 | 8(–) | |
YY1 | Yin-Yang 1 transcription factor | chr14:100,240,497-100,240,751 | 26 | 255 | 8(–) 22(–) | |