Fig. 7
From: DNA methylation at modifier genes of lung disease severity is altered in cystic fibrosis
DNA methylation at GSTM3. The mean DNA methylation at GSTM3 depended on pulmonary severity (ANOVA p = 0.016) (a). The heat maps represent DNA methylation at nine CpG dinucleotides in NEC samples; white lines represent missing data (b). Low methylation levels correlated with the GSTM3*B allele both in blood (Spearman’s r = −0.42, p = 3 10−4) (c) and NEC samples (Spearman’s r =−0.43, p = 5 10−4) (d). CFM mild CF patient, CFI intermediary CF patient, CFS severe CF patient. The horizontal line in the dot plots indicates the median in each group. A/A homozygous GSTM3*A, A/B heterozygous, B/B homozygous GSTM3*B