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Fig. 4 | Clinical Epigenetics

Fig. 4

From: DNA methylation at modifier genes of lung disease severity is altered in cystic fibrosis

Fig. 4

DNA methylation at HMOX1. The dot plots represent the mean DNA methylation of HMOX1 in CF patients compared with controls in NEC (Student p = 0.018) (a) and in blood (Wilcoxon p = 0.009) samples (b). DNA methylation levels depended on pulmonary severity (NEC, ANOVA p = 0.052 (c); blood, Kruskal-Wallis p = 0.035 (d)). The horizontal line indicates the median in each group. The heat maps represent the DNA methylation at five CpG dinucleotides in NEC (e) and blood (f) samples. White lines represent missing data. CFM mild CF patient, CFI intermediary CF patient, CFS severe CF patient

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