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Table 1 Clinicopathological data of 71 biliary tract cancer patients included in the tissue study. Associations of clinicopathological data with relative DNA methylation of SHOX2 and SEPT9 in tumor tissue

From: Promoter hypermethylation of SHOX2 and SEPT9 is a potential biomarker for minimally invasive diagnosis in adenocarcinomas of the biliary tract

    SHOX2 methylation SEPT9 methylation
Clinicopathological data n (%)
    p value (n) p value (n)
Tumor location
 GBC 17 (24)   
 IHC 25 (35)   
 PHC (Klatskin tumor) 22 (31)   
 DC 7 (10)   
 GBC vs. CC    0.46 (55) 0.014* (55)
Gender
 Male 42 (59)   
 Female 29 (41)   
 Male vs. female    0.10 (55) 0.14 (55)
Age at diagnosis
 ≤60 years 31 (44)   
 >60 years 40 (56)   
 Median age [years] 63 NA   
 Mean age [years] 62 NA   
 Range [years] 36–83 NA   
 ≤60 vs. >60 years    0.57 (55) 0.031* (55)
Tumor grade
 G1 5 (7)   
 G2 33 (46.5)   
 G3 33 (46.5)   
 G1, G2, vs. G3    0.22 (55) 0.68 (55)
Tumor stage
 T1 10 (14)   
 T2 17 (24)   
 T3 38 (53.5)   
 T4 6 (8.5)   
 T1, T2 vs. T3, T4    0.51 (55) 0.013* (55)
Lymph node status
 N0 32 (45.1)   
 N1 15 (21.1)   
 N2 1 (1.4)   
 Unknown 23 (32.4)   
 N0 vs. N1, N2    0.19 (39) 0.30 (39)
Venous invasion
 V0 42 (59)   
 V1 19 (27)   
 Unknown 10 (14)   
 V0 vs. V1    0.97 (48) 0.76 (48)
Lymphatic invasion
 L0 34 (48)   
 L1 20 (28)   
 Unknown 17 (24)   
 L0 vs. L1    0.67 (42) 0.70 (42)
Perineural invasion
 Pn0 17 (24)   
 Pn1 35 (49)   
 Unknown 19 (27)   
 Pn0 vs. Pn1    0.37 (41) 0.82 (41)
Distant metastases
 M0 65 (91.5)   
 M1 6 (8.5)   
 M0 vs. M1    0.32 (55) 0.36 (55)
UICC stage
 UICC I 4 (6)   
 UICC II 9 (13)   
 UICC III 28 (39)   
 UICC IV 10 (14)   
 Unknown 20 (28)   
 UICC I, II vs. UICC III, IV    0.08 (41) 0.06 (41)
Surgical margin
 R0 52 (73)   
 R1 19 (27)   
 R0 vs. R1    0.24 (55) 0.66 (55)
Follow-up
 Follow-up available 71 (100)   
 Median follow-up [months] 15 NA   
 Mean follow-up [months] 23 NA   
 Range [months] 0–104 NA   
 Deceased 50 (70)   
 Censored 21 (30)   
  1. p values refer to the Mann-Whitney U test
  2. *p < 0.05