Fig. 4

Normalized 5-hmC levels in CLL B cells cultured alone in RPMI or with conditioned medium (CM). The different conditioned media were obtained from supernatants of 24 h cultures of a BMSC, b CLL B cells + BMSC with contact, and c CLL B cells + BMSC without contact (separated by a 0.4-μm pore-size filter). Statistical differences were assessed using the paired Wilcoxon non-parametric test