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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Increased Set1 binding at the promoter induces aberrant epigenetic alterations and up-regulates cyclic adenosine 5'-monophosphate response element modulator alpha in systemic lupus erythematosus

Fig. 5

Relationships between H3K4me3, DNA methylation, and DNMT3a. a Negative correlation between H3K4me3 enrichment and DNA methylation level at the CREMα promoter in SLE CD4+ T cells. b Relative level of DNMT3a binding within the CREMα promoter region in CD4+ T cells from 20 SLE patients and 20 healthy controls were detected by ChIP and real-time PCR. Results were normalized to input DNA (total chromatin). All data are representative from three independent experiments. c Negative correlation between H3K4me3 enrichment and DNMT3a binding at the CREMα promoter in SLE CD4+ T cells

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Clinical Epigenetics

ISSN: 1868-7083

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