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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Increased Set1 binding at the promoter induces aberrant epigenetic alterations and up-regulates cyclic adenosine 5'-monophosphate response element modulator alpha in systemic lupus erythematosus

Fig. 3

Set1 and MLL1 binding at the CREMα promoter in SLE and control CD4+ T cells. a, b Relative levels of Set1 (a) and MLL1 (b) binding within the CREMα promoter region in SLE and healthy CD4+ T cells were analyzed by ChIP and real-time PCR. Results were normalized to input DNA (total chromatin). c Positive correlation between Set1 promoter binding and H3K4me3 level in SLE CD4+ T cells. d Positive correlation between Set1 promoter binding and CREMα mRNA level in SLE CD4+ T cells. All experiments were repeated three times

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Clinical Epigenetics

ISSN: 1868-7083

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