Augmentation of histone deacetylase 3 (HDAC3) epigenetic signature at the interface of proinflammation and insulin resistance in patients with type 2 diabetes

Table 2 Pearson correlation analysis of HDAC3 activity/HDAC3 mRNA expression with biochemical and molecular parameters in the study groups

Variables	HDAC3 activity		HDAC3 mRNA
Variables	r value	p value	r value	p value
Age (years)	−0.144	0.318	0.066	0.739
BMI (kg/m²)	0.208	0.147	0.218	0.265
Waist (cm)	0.028	0.865	0.121	0.602
Systolic blood pressure (mmHg)	0.098	0.498	0.233	0.233
Diastolic blood pressure (mmHg)	−0.015	0.916	0.199	0.31
Fasting plasma glucose (mg/dL)	0.611	<0.001	0.602	0.001
HbA1c (%)	0.474	0.001	0.447	0.017
HOMA-IR	0.526	<0.001	0.378	0.047
Plasma TNF-α	0.534	<0.001	0.417	0.027
Plasma IL-6	0.617	<0.001	0.381	0.045
Serum cholesterol (mg/dl)	−0.181	0.210	0.044	0.825
Serum triglycerides (mg/dl)	0.106	0.465	0.152	0.439
LDL cholesterol (mg/dl)	−0.19	0.185	0.023	0.908
HDL cholesterol (mg/dl)	−0.161	0.263	−0.052	0.792
TNF-α mRNA expression	0.175	0.374	0.027	0.892
IL-6 mRNA expression	0.167	0.395	−0.016	0.935
NFκB mRNA expression	0.627	<0.001	0.118	0.559
IL1-β mRNA expression	0.643	0.001	0.247	0.255
MCP-1 mRNA expression	0.521	0.004	0.846	<0.001
SOCS3 mRNA expression	0.708	<0.001	0.557	0.002
TLR2 mRNA expression	0.484	0.009	0.156	0.437
TLR4 mRNA expression	0.444	0.018	0.234	0.240
DBC1 mRNA expression	−0.396	0.037	−0.315	0.109
HDAC3 mRNA expression	0.549	0.002	–	–
HDAC3 activity	–	–	0.549	0.002
Sirt1 mRNA expression	−0.414	0.029	−0.125	0.527

ISSN: 1868-7083