From: Smoking-associated DNA methylation markers predict lung cancer incidence
CpG site | Methylation levela | Controls | Cases | OR (95% CI) | ||
---|---|---|---|---|---|---|
Model 1b | Model 2c | Model 3d | ||||
AHRR_cg05575921 | ≥85 (quartile 4) | 59 | 6 | Ref. | Ref. | Ref. |
<85 (quartile 3) | 73 | 1 | ||||
<80 (quartile 2) | 58 | 11 | 4.13 (1.48–11.52) | 3.70 (1.12–12.22) | 4.63 (1.27–16.80) | |
<68 (quartile 1) | 45 | 47 | 23.93 (9.61–59.57) | 17.17 (4.91–60.03) | 15.86 (4.18–60.17) | |
Per SD less methylation | – | 2.61 (2.02–3.37) | 2.58 (1.69–3.94) | 2.37 (1.46–3.85) | ||
6p21.33_cg06126421 | ≥73 (quartile 4) | 63 | 4 | Ref. | Ref. | Ref. |
<73 (quartile 3) | 76 | 6 | ||||
<66 (quartile 2) | 50 | 12 | 3.90 (1.52–9.98) | 3.00 (1.06–8.48) | 4.08 (1.27–13.07) | |
<57 (quartile 1) | 46 | 43 | 15.55 (6.89–35.10) | 6.92 (2.63–18.18) | 8.12 (2.69–24.48) | |
Per SD less methylation | – | 2.92 (2.15–3.98) | 2.11 (1.45–3.05) | 2.11 (1.39–3.19) | ||
F2RL3_cg03636183 | ≥81 (quartile 4) | 113 | 5 | Ref. | Ref. | Ref. |
<81 (quartile 3) | 39 | 5 | ||||
<78 (quartile 2) | 40 | 9 | 3.91 (1.45–10.55) | 2.75 (0.91–8.37) | 2.45 (0.72–8.31) | |
<73 (quartile 1) | 43 | 46 | 19.25 (8.59–43.15) | 10.84 (4.03–29.19) | 10.55 (3.44–32.31) | |
Per SD less methylation | – | 2.46 (1.90–3.19) | 1.86 (1.33–2.60) | 1.72 (1.17–2.51) |