Aberrant DNA hypermethylation-silenced SOX21-AS1 gene expression and its clinical importance in oral cancer

Clinical Epigenetics

Table 3 Univariate and multivariate Cox’s regression analysis of SOX21-AS1 expression for disease-specific survival and disease-free survival of OSCC patients

Variable	Number (%)	Number of events	Univariate analysis			Multivariate analysis
Variable	Number (%)	Number of events	Hazard ratio	95% CI	P value	Hazard ratio	95% CI	P value^a
Disease-specific survival
SOX21-AS1
High	57 (66.3)	8	1.00			1.00
Low	29 (33.7)	10	3.07	1.21–7.78	0.018	5.66	1.85–17.30	0.002
Disease-free survival
SOX21-AS1
High	57 (66.3)	16	1.00			1.00
Low	29 (33.7)	10	1.60	0.72–3.54	0.249	2.96	1.14–7.64	0.025

The italic indicated p value <0.05
^a P values were estimated by multiple Cox’s regression, in which adjusted for cell differentiation (moderate and poor vs well), AJCC pathological stage (stages III and IV vs stages I and II), and SOX21 (high vs low)

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