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Table 1 Collagen XVII α1 expression in normal, hyperplastic, and tumor breast tissue

From: In epithelial cancers, aberrant COL17A1 promoter methylation predicts its misexpression and increased invasion

Variable

Number positive/total (%)

p value vs normala,b

Other (p value)a,b

All samples

 Normal breast

24/57 (42)

  

 Hyperplasia

11/20 (55)

0.2308

 Ductal carcinoma

33/150 (22)

0.0038

Grade

 1

4/34 (12)

0.0019

 

 2

25/102 (25)

0.0174

 3

2/10 (20)

0.1665

Stage

 I

0/6 (0)

0.0480

I/II vs III/VI (0.0287)

 II

29/105 (28)

0.0452

 I/II

29/111 (26)

0.0273

 III

4/33 (12)

0.0024

 IV

0/6 (0)

0.0480

 III/IV

4/39 (10)

0.0005

Tumor invasion

 T1

2/8 (25)

0.3015

T1/2 vs T3/4 (0.0143)

 T2

25/89 (28)

0.0587

 T1/T2

27/97 (28)

0.0512

 T3

4/28 (14)

0.0084

 T4

2/25 (8)

0.0015

 T3/T4

6/53 (11)

0.0002

Nodal status

 N0

25/98 (26)

0.0254

0 vs 1 (0.1625)

 N1

6/38 (16)

0.0057

0/1 vs 2/3 (0.3657)

 N2

2/12 (17)

0.0894

 N3

0/2 (0)

0.3477

Metastasis

 M0

33/146 (23)

0.0052

M0 vs M1 (0.3659)

 M1

0/4 (0)

0.1266

Estrogen receptor status

 ER+

13/63 (21)

0.0093

ER+ vs ER− (0.5000)

 ER−

15/78 (19)

0.0035

Progesterone receptor status

 PR+

11/44 (25)

0.0562

PR+ vs PR− (0.2177)

 PR−

17/96 (18)

0.0011

HER2 status

 HER2-

4/32 (13)

0.0031

HER2− vs HER2+ (0.1702)

 HER2+

24/108 (22)

0.0068

Age/menopausal status

 <48

21/71 (30)

0.0988

<48 vs ≥48 (0.0268)

 48–54

6/37 (16)

0.0040

<51 vs ≥51 (0.0218)

 >54

6/42 (14)

0.0024

<54 vs ≥54 (0.0480)

<48 vs ≥54 (0.0263)

  1. aCalculated by Fisher’s exact test
  2. b p values in italic font remain statistically significant after accounting for multiple testing using a false discovery rate (FDR) of 5% [40]