Fig. 5

The COL17A1 promoter is hypomethylated in head and neck and lung cancers. a–c Methylation status of the COL17A1 promoter in head and neck squamous cell carcinoma (SCC), lung adenocarcinoma, and lung SCC using the respective TCGA datasets [41–43], as in Fig. 4c. p values: Mann-Whitney U test. d–f Scatter plots of COL17A1 promoter methylation compared to normalized gene expression for indicated cancer types, as in Fig. 4d. p values: Spearman correlation for linear regression. g Box plot comparing the absolute COL17A1 mRNA levels in five epithelial tumor types and their respective matched normal control tissues. Data were extracted from TCGA RNAseq datasets [21, 22, 41–43]. N normal tissues, T tumor tissues. Sample numbers are indicated below each box. p values: Mann-Whitney U tests. p value summaries: **p < 0.01; ***p < 0.001; ****p < 0.0001