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Table 4 Prediction model results

From: Discovery and replication of a peripheral tissue DNA methylation biosignature to augment a suicide prediction model

Cohort

N

Outcome

Cases

Controls

Interaction

AUC

95 % CI

P value

GenRED Offspring blood

18

Attempt

4

14

Biosignature

0.768

0.47–1

0.052

GenRED Offspring saliva

20

Ideation

5

15

Biosignature

0.807

0.59–1

0.011

PPD cohort blood

51

Ideation

8

43

Biosignature

0.884

0.75–1

0.041

GTP blood

376

Ideation

63

313

Biosignature

0.500

0.42–0.58

0.724

GTP subset blood

115

Ideation

6

109

Biosignature

0.727

0.59–0.87

0.050

GenRED Offspring blood

18

Attempt

4

14

% myeloid

0.732

0.40–1

0.28

GenRED Offspring saliva

20

Ideation

5

15

% myeloid

0.788

0.56–1

0.28

PPD cohort blood

51

Ideation

8

43

% myeloid

0.834

0.61–1

0.003

GTP subset blood

115

Ideation

6

109

% myeloid

0.728

0.55–0.9

0.99

  1. Prediction model results for all cohorts using either the interaction biosignature or the myeloid-derived proportion as the interaction term. P values are derived from Monte Carlo permutation