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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Discovery and replication of a peripheral tissue DNA methylation biosignature to augment a suicide prediction model

Fig. 1

Discovery of interaction biosignature probes and prediction of suicidal ideation using interaction biosignature in multiple cohorts. a Volcano plot in prefrontal cortex neurons (cases, N = 22; controls, N = 23) of the interaction of individual probe methylation with rs7208505 methylation and genotype. b Probes with an interaction P value <0.005 (N = 669) were optimized for prediction of SA in GenRED Offspring blood. Probes with an AUC prediction above 0.825 (N = 72) were used to train a PCA model. c ROC curves of prediction of SI in GenRED Offspring saliva and PPD cohort blood using the first eigenvectors of predicted PCAs. d ROC curves of prediction of SI in the whole GTP cohort and a subset of drug-naïve, non-PTSD individuals (cases = 6; controls = 109)

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