Intra-individual changes in DNA methylation not mediated by cell-type composition are correlated with aging during childhood

Table 1 Significant aDMPs with a direct effect on aging (n = 26)

Chr	Position	Adjusted p value	Mean difference 2 to 10 years	Mean difference 10 to 16 years	Mean difference 2 to 16 years	Gene	In CGI
1	69596098	0.0066	−0.0245	−0.0697	−0.0941	–	No
1	156883344^a	0.0001	0.3168	0.0722	0.3891	PEAR1	No
1	156883372^a	0.0463	0.1817	0.0111	0.1928	PEAR1	No
1	228400131	0.0263	0.2586	0.1004	0.3590	OBSNC	Yes
1	228400135	0.0401	0.1595	0.0644	0.2239	OBSNC	Yes
1	228400157	0.0463	0.2250	0.0287	0.2537	OBSNC	Yes
1	228400210	0.0271	0.1841	0.0520	0.2361	OBSNC	Yes
1	228400285	0.0427	0.2845	0.1512	0.4356	OBSNC	Yes
2	233251546	0.0263	0.3498	0.0427	0.3926	ECEL1P2	Yes
2	233251551	0.0097	0.3378	0.0274	0.3652	ECEL1P2	Yes
4	117279915	0.0066	−0.1557	−0.1123	−0.2681	–	No
4	117280012	0.0284	−0.2395	−0.0671	−0.3066	–	No
5	78985800^a	0.0455	0.1730	0.1003	0.2732	CMYA5	No
6	158097037	0.0409	0.2276	0.0110	0.2386	–	No
7	100463812^a	0.0254	−0.3432	−0.0831	−0.4262	TRIP6	Yes
8	6656321	0.0090	−0.1563	−0.0884	−0.2447	–	No
9	136474402	0.0263	0.0524	0.0942	0.1466	–	Yes
9	140173334	0.0066	0.2576	0.0925	0.3501	C9orf167	Yes
9	140173378	0.0229	0.0922	0.0555	0.1477	C9orf167	Yes
10	129537308	0.0066	0.3634	0.0584	0.4218	FOX12	Yes
14	105881000	0.0263	0.0370	0.0214	0.0584	–	No
17	1179934	0.0344	−0.1037	−0.1406	−0.2443	TUSC5	No
17	75421287	0.0463	0.0196	0.0271	0.0467	SEPT9	No
17	76355061^a	0.0066	0.2076	0.1098	0.3174	SOCS3	Yes
17	78262132	0.0486	0.1670	0.0400	0.2069	RNF213	No
20	62679572^a	0.0401	0.1111	0.0882	0.1993	SOX18	Yes

ISSN: 1868-7083